Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093798984> ?p ?o ?g. }
- W2093798984 endingPage "1123" @default.
- W2093798984 startingPage "1115" @default.
- W2093798984 abstract "Regulator of calcineurin 1 (RCAN1) is located on the Down syndrome critical region (DSCR) locus in human chromosome 21. In this study, we investigated the functional role of RCAN1 in the reactive oxygen species (ROS)-mediated neuronal death signaling. We found that RCAN1 was able to protect the cells from H(2)O(2) -induced cytotoxicity. The expression of RCAN1 caused an inhibition of the H(2)O(2) -induced activation of mitogen-activated protein kinases (MAPKs) and AP-1. In contrast, RCAN1 significantly enhanced the activity of cAMP response element-binding protein (CREB). Furthermore, RCAN1 induced the expression of the CREB target gene, Bcl-2. Consistently, knockdown of endogenous RCAN1 using shRNA down regulated the phosphorylation of CREB and the expression of Bcl-2, which protects the cells from H(2)O(2) -induced cytotoxicity. Our data provide a new mechanism for the cytoprotective function of RCAN1 in response to oxidant-induced apoptosis." @default.
- W2093798984 created "2016-06-24" @default.
- W2093798984 creator A5055128041 @default.
- W2093798984 creator A5064331188 @default.
- W2093798984 creator A5066219125 @default.
- W2093798984 date "2013-03-14" @default.
- W2093798984 modified "2023-09-23" @default.
- W2093798984 title "CREB-mediated Bcl-2 expression contributes to RCAN1 protection from hydrogen peroxide-induced neuronal death" @default.
- W2093798984 cites W1874291746 @default.
- W2093798984 cites W1972528195 @default.
- W2093798984 cites W1989053288 @default.
- W2093798984 cites W1992967227 @default.
- W2093798984 cites W2001715059 @default.
- W2093798984 cites W2020290862 @default.
- W2093798984 cites W2024195272 @default.
- W2093798984 cites W2025297620 @default.
- W2093798984 cites W2025503860 @default.
- W2093798984 cites W2028206199 @default.
- W2093798984 cites W2028242823 @default.
- W2093798984 cites W2037561499 @default.
- W2093798984 cites W2038043012 @default.
- W2093798984 cites W2039244674 @default.
- W2093798984 cites W2043912051 @default.
- W2093798984 cites W2044517483 @default.
- W2093798984 cites W2049439285 @default.
- W2093798984 cites W2064920938 @default.
- W2093798984 cites W2068252839 @default.
- W2093798984 cites W2075479483 @default.
- W2093798984 cites W2090471325 @default.
- W2093798984 cites W2101326303 @default.
- W2093798984 cites W2102403850 @default.
- W2093798984 cites W2124988646 @default.
- W2093798984 cites W2125876685 @default.
- W2093798984 cites W2126606149 @default.
- W2093798984 cites W2126770714 @default.
- W2093798984 cites W2135725455 @default.
- W2093798984 cites W2151575309 @default.
- W2093798984 cites W2156504280 @default.
- W2093798984 cites W2163259980 @default.
- W2093798984 cites W2163586931 @default.
- W2093798984 cites W2167584205 @default.
- W2093798984 doi "https://doi.org/10.1002/jcb.24452" @default.
- W2093798984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23150431" @default.
- W2093798984 hasPublicationYear "2013" @default.
- W2093798984 type Work @default.
- W2093798984 sameAs 2093798984 @default.
- W2093798984 citedByCount "14" @default.
- W2093798984 countsByYear W20937989842013 @default.
- W2093798984 countsByYear W20937989842014 @default.
- W2093798984 countsByYear W20937989842015 @default.
- W2093798984 countsByYear W20937989842016 @default.
- W2093798984 countsByYear W20937989842017 @default.
- W2093798984 countsByYear W20937989842018 @default.
- W2093798984 countsByYear W20937989842019 @default.
- W2093798984 crossrefType "journal-article" @default.
- W2093798984 hasAuthorship W2093798984A5055128041 @default.
- W2093798984 hasAuthorship W2093798984A5064331188 @default.
- W2093798984 hasAuthorship W2093798984A5066219125 @default.
- W2093798984 hasConcept C104317684 @default.
- W2093798984 hasConcept C11960822 @default.
- W2093798984 hasConcept C153911025 @default.
- W2093798984 hasConcept C1629964 @default.
- W2093798984 hasConcept C173396325 @default.
- W2093798984 hasConcept C185592680 @default.
- W2093798984 hasConcept C190283241 @default.
- W2093798984 hasConcept C48349386 @default.
- W2093798984 hasConcept C55493867 @default.
- W2093798984 hasConcept C86339819 @default.
- W2093798984 hasConcept C86803240 @default.
- W2093798984 hasConcept C95444343 @default.
- W2093798984 hasConcept C97029542 @default.
- W2093798984 hasConceptScore W2093798984C104317684 @default.
- W2093798984 hasConceptScore W2093798984C11960822 @default.
- W2093798984 hasConceptScore W2093798984C153911025 @default.
- W2093798984 hasConceptScore W2093798984C1629964 @default.
- W2093798984 hasConceptScore W2093798984C173396325 @default.
- W2093798984 hasConceptScore W2093798984C185592680 @default.
- W2093798984 hasConceptScore W2093798984C190283241 @default.
- W2093798984 hasConceptScore W2093798984C48349386 @default.
- W2093798984 hasConceptScore W2093798984C55493867 @default.
- W2093798984 hasConceptScore W2093798984C86339819 @default.
- W2093798984 hasConceptScore W2093798984C86803240 @default.
- W2093798984 hasConceptScore W2093798984C95444343 @default.
- W2093798984 hasConceptScore W2093798984C97029542 @default.
- W2093798984 hasIssue "5" @default.
- W2093798984 hasLocation W20937989841 @default.
- W2093798984 hasLocation W20937989842 @default.
- W2093798984 hasOpenAccess W2093798984 @default.
- W2093798984 hasPrimaryLocation W20937989841 @default.
- W2093798984 hasRelatedWork W1968684437 @default.
- W2093798984 hasRelatedWork W1976441097 @default.
- W2093798984 hasRelatedWork W2006487417 @default.
- W2093798984 hasRelatedWork W2018080123 @default.
- W2093798984 hasRelatedWork W2090522583 @default.
- W2093798984 hasRelatedWork W2114105585 @default.
- W2093798984 hasRelatedWork W2371090837 @default.
- W2093798984 hasRelatedWork W3018495632 @default.
- W2093798984 hasRelatedWork W3045989176 @default.