FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093804110> ?p ?o ?g. }

• W2093804110 endingPage "183" @default.
• W2093804110 startingPage "170" @default.
• W2093804110 abstract "Arylamine N-acetyltransferases (NATs) catalyse the N-acetylation of arylamines, arylhydroxylamines and arylhydrazines with the acetyl group being transferred from acetylCoenzyme A. As a result of many recent advances in NAT research there have been many recent reviews and the present paper gives a flavour of the excitement in the field. The NATs, which are cytosolic, were early examples of pharmacogenetic variation. Polymorphism in isoniazid inactivation resulting in slow acetylation was subsequently found to be due to SNPs in the gene encoding the human isoenzyme NAT2. There are two polymorphic genes (NAT1 and NAT2) encoded with a third pseudogene (NATP) at human 8p21.3. The gene structure of NAT1 and NAT2, with a single (NAT2) or multiple (NAT1) distant non-coding exons showing tissue specific splicing, opens possibilities for effects of polymorphisms outside the single coding exon. In humans, the substrate specificities of NAT1 and NAT2 are overlapping but distinct. The NAT2 isoenzyme, predominantly in liver and gut, acetylates sulphamethazine and arylhydrazine compounds. Slow acetylators are at increased risk of toxicity, e.g. isoniazid induced neurotoxicity and hydralazine-induced lupus. The human NAT1 isoenzyme is also polymorphic. It is expressed in many tissues, particularly in oestrogen receptor positive breast cancers. Human NAT1 has an endogenous role in acetylation of a folate catabolite with in vivo evidence from transgenic mice lacking the equivalent gene. For nomenclature see http://louisville.edu/medschool/pharmacology/NAT.html, the website maintained by David Hein. NAT homologues have been identified by bioinformatics analyses in zebrafish and these sequences are described, although the proteins have not yet been characterized. The first NAT crystallographic structure from Salmonella typhimurium identified the mechanism of acetyl transfer via a catalytic triad of Cys, His and Asp residues each essential for activity in all NATs. NATs from mycobacteria aided in identifying the substrate binding site and the acetylCoA binding pocket. Studies on the eukaryotic enzymes by NMR and crystallography have facilitated understanding substrate specificities of human NAT1 (5-aminosalicylate and p-aminobenzoic acid) and human NAT2 (sulphamethazine). The effect of “slow acetylator” SNPs in the coding region predominantly act through creating unstable protein that aggregates intracellularly prior to ubiquitination and degradation." @default.
• W2093804110 created "2016-06-24" @default.
• W2093804110 creator A5002275003 @default.
• W2093804110 creator A5010669426 @default.
• W2093804110 creator A5014432473 @default.
• W2093804110 creator A5016346851 @default.
• W2093804110 creator A5025871273 @default.
• W2093804110 creator A5071196257 @default.
• W2093804110 creator A5085494254 @default.
• W2093804110 date "2008-12-01" @default.
• W2093804110 modified "2023-09-24" @default.
• W2093804110 title "Arylamine N-acetyltransferases: Structural and functional implications of polymorphisms" @default.
• W2093804110 cites W1485107652 @default.
• W2093804110 cites W1491175805 @default.
• W2093804110 cites W1516667778 @default.
• W2093804110 cites W1522302756 @default.
• W2093804110 cites W1528082070 @default.
• W2093804110 cites W1580220829 @default.
• W2093804110 cites W1581151107 @default.
• W2093804110 cites W1587924678 @default.
• W2093804110 cites W1600133349 @default.
• W2093804110 cites W1623676777 @default.
• W2093804110 cites W1757108108 @default.
• W2093804110 cites W1839665474 @default.
• W2093804110 cites W1849506433 @default.
• W2093804110 cites W1965532359 @default.
• W2093804110 cites W1967610996 @default.
• W2093804110 cites W1969105152 @default.
• W2093804110 cites W1969709116 @default.
• W2093804110 cites W1977570377 @default.
• W2093804110 cites W1978365776 @default.
• W2093804110 cites W1979047461 @default.
• W2093804110 cites W1980571658 @default.
• W2093804110 cites W1985232100 @default.
• W2093804110 cites W1996770386 @default.
• W2093804110 cites W1998255749 @default.
• W2093804110 cites W2000498456 @default.
• W2093804110 cites W2002280541 @default.
• W2093804110 cites W2002397610 @default.
• W2093804110 cites W2004373161 @default.
• W2093804110 cites W2006739670 @default.
• W2093804110 cites W2009352609 @default.
• W2093804110 cites W2014264831 @default.
• W2093804110 cites W2016064391 @default.
• W2093804110 cites W2019329593 @default.
• W2093804110 cites W2022928028 @default.
• W2093804110 cites W2029988617 @default.
• W2093804110 cites W2032443268 @default.
• W2093804110 cites W2035372660 @default.
• W2093804110 cites W2039408159 @default.
• W2093804110 cites W2042897001 @default.
• W2093804110 cites W2043203418 @default.
• W2093804110 cites W2043512288 @default.
• W2093804110 cites W2045492912 @default.
• W2093804110 cites W2046741367 @default.
• W2093804110 cites W2050276116 @default.
• W2093804110 cites W2052773860 @default.
• W2093804110 cites W2053419614 @default.
• W2093804110 cites W2053867451 @default.
• W2093804110 cites W2053878425 @default.
• W2093804110 cites W2054404209 @default.
• W2093804110 cites W2054454959 @default.
• W2093804110 cites W2055266236 @default.
• W2093804110 cites W2055786949 @default.
• W2093804110 cites W2058372101 @default.
• W2093804110 cites W2060163129 @default.
• W2093804110 cites W2060358207 @default.
• W2093804110 cites W2060867647 @default.
• W2093804110 cites W2062626341 @default.
• W2093804110 cites W2063360787 @default.
• W2093804110 cites W2064899351 @default.
• W2093804110 cites W2065619930 @default.
• W2093804110 cites W2066959869 @default.
• W2093804110 cites W2067398743 @default.
• W2093804110 cites W2069455052 @default.
• W2093804110 cites W2070669906 @default.
• W2093804110 cites W2070858213 @default.
• W2093804110 cites W2074330397 @default.
• W2093804110 cites W2077249120 @default.
• W2093804110 cites W2077535572 @default.
• W2093804110 cites W2078433308 @default.
• W2093804110 cites W2081641129 @default.
• W2093804110 cites W2082156275 @default.
• W2093804110 cites W2082802949 @default.
• W2093804110 cites W2084185692 @default.
• W2093804110 cites W2085231301 @default.
• W2093804110 cites W2087489614 @default.
• W2093804110 cites W2088852867 @default.
• W2093804110 cites W2095038216 @default.
• W2093804110 cites W2100289966 @default.
• W2093804110 cites W2100357455 @default.
• W2093804110 cites W2100878389 @default.
• W2093804110 cites W2102821513 @default.
• W2093804110 cites W2104551057 @default.
• W2093804110 cites W2106321527 @default.
• W2093804110 cites W2107181199 @default.
• W2093804110 cites W2110045183 @default.
• W2093804110 cites W2111780976 @default.

• next