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• W2093812780 abstract "Neurotransmitter release from synaptic vesicle fusion is the fundamental mechanism for neuronal communication at synapses. Evoked release following an action potential has been well characterized for its function in activating the postsynaptic cell, but the significance of spontaneous release is less clear. Using transgenic tools to image single synaptic vesicle fusion events at individual release sites (active zones) in Drosophila, we characterized the spatial and temporal dynamics of exocytotic events that occur spontaneously or in response to an action potential. We also analyzed the relationship between these two modes of fusion at single release sites. A majority of active zones participate in both modes of fusion, although release probability is not correlated between the two modes of release and is highly variable across the population. A subset of active zones is specifically dedicated to spontaneous release, indicating a population of postsynaptic receptors is uniquely activated by this mode of vesicle fusion. Imaging synaptic transmission at individual release sites also revealed general rules for spontaneous and evoked release, and indicate that active zones with similar release probability can cluster spatially within individual synaptic boutons. These findings suggest neuronal connections contain two information channels that can be spatially segregated and independently regulated to transmit evoked or spontaneous fusion signals." @default.
• W2093812780 created "2016-06-24" @default.
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• W2093812780 date "2013-10-30" @default.
• W2093812780 modified "2023-10-15" @default.
• W2093812780 title "Spontaneous and Evoked Release Are Independently Regulated at Individual Active Zones" @default.
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• W2093812780 doi "https://doi.org/10.1523/jneurosci.3334-13.2013" @default.
• W2093812780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3812501" @default.
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