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- W2093826863 endingPage "1082" @default.
- W2093826863 startingPage "1046" @default.
- W2093826863 abstract "Gram-negative bacteria express a wide variety of organelles on their cell surface. These surface structures may be the end products of secretion systems, such as the hair-like fibers assembled by the chaperone/usher (CU) and type IV pilus pathways, which generally function in adhesion to surfaces and bacterial-bacterial and bacterial-host interactions. Alternatively, the surface organelles may be integral components of the secretion machinery itself, such as the needle complex and pilus extensions formed by the type III and type IV secretion systems, which function in the delivery of bacterial effectors inside host cells. Bacterial surface structures perform functions critical for pathogenesis and have evolved to withstand forces exerted by the external environment and cope with defenses mounted by the host immune system. Given their essential roles in pathogenesis and exposed nature, bacterial surface structures also make attractive targets for therapeutic intervention. This review will describe the structure and function of surface organelles assembled by four different Gram-negative bacterial secretion systems: the CU pathway, the type IV pilus pathway, and the type III and type IV secretion systems." @default.
- W2093826863 created "2016-06-24" @default.
- W2093826863 creator A5013547809 @default.
- W2093826863 creator A5022808419 @default.
- W2093826863 creator A5039688220 @default.
- W2093826863 date "2012-11-01" @default.
- W2093826863 modified "2023-10-06" @default.
- W2093826863 title "Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function" @default.
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