FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093842115> ?p ?o ?g. }

• W2093842115 endingPage "186" @default.
• W2093842115 startingPage "177" @default.
• W2093842115 abstract "Ligaments have limited regenerative potential and as a consequence, repair is protracted and results in a mechanically inferior tissue more scar-like than native ligament. We previously reported that a single injection of interleukin-1 receptor antagonist (IL-1Ra) delivered at the time of injury, decreased the number of M2 macrophage-associated inflammatory cytokines. Based on these results, we hypothesized that IL-1Ra administered after injury and closer to peak inflammation (as would occur clinically), would more effectively decrease inflammation and thereby improve healing. Since IL-1Ra has a short half-life, we also investigated the effect of multiple injections. The objective of this study was to elucidate healing of a medial collateral ligament (MCL) with either a single IL-1Ra injection delivered one day after injury or with multiple injections of IL-1Ra on days 1, 2, 3, and 4. One day after MCL injury, rats received either single or multiple injections of IL-1Ra or PBS. Tissue was then collected at days 5 and 11. Both single and multiple IL-1Ra injections reduced inflammatory cytokines, but did not change mechanical behavior. A single injection of IL-1Ra also reduced the number of myofibroblasts and increased type I procollagen. Multiple IL-1Ra doses provided no additive response and, in fact, reduced the M2 macrophages. Based on these results, a single dose of IL-1Ra was better at reducing the MCL-derived inflammatory cytokines compared to multiple injections. The changes in type I procollagen and myofibroblasts further suggest a single injection of IL-1Ra enhanced repair of the ligament but not sufficiently to improve functional behavior." @default.
• W2093842115 created "2016-06-24" @default.
• W2093842115 creator A5016707131 @default.
• W2093842115 creator A5030384497 @default.
• W2093842115 creator A5045010323 @default.
• W2093842115 creator A5060275333 @default.
• W2093842115 creator A5075168513 @default.
• W2093842115 creator A5075484607 @default.
• W2093842115 creator A5081705219 @default.
• W2093842115 creator A5085115078 @default.
• W2093842115 date "2014-04-18" @default.
• W2093842115 modified "2023-09-28" @default.
• W2093842115 title "Interleukin-1 receptor antagonist modulates inflammation and scarring after ligament injury" @default.
• W2093842115 cites W148753544 @default.
• W2093842115 cites W1515994079 @default.
• W2093842115 cites W1892427918 @default.
• W2093842115 cites W1964402687 @default.
• W2093842115 cites W1966848960 @default.
• W2093842115 cites W1983357763 @default.
• W2093842115 cites W1984002529 @default.
• W2093842115 cites W1990068813 @default.
• W2093842115 cites W1990083653 @default.
• W2093842115 cites W1997957358 @default.
• W2093842115 cites W1998574307 @default.
• W2093842115 cites W2001587441 @default.
• W2093842115 cites W2001717792 @default.
• W2093842115 cites W2005552040 @default.
• W2093842115 cites W2016637496 @default.
• W2093842115 cites W2023771664 @default.
• W2093842115 cites W2025377207 @default.
• W2093842115 cites W2026809669 @default.
• W2093842115 cites W2031843136 @default.
• W2093842115 cites W2038689279 @default.
• W2093842115 cites W2050650884 @default.
• W2093842115 cites W2051114553 @default.
• W2093842115 cites W2053067638 @default.
• W2093842115 cites W2061123122 @default.
• W2093842115 cites W2077136301 @default.
• W2093842115 cites W2102232815 @default.
• W2093842115 cites W2108723188 @default.
• W2093842115 cites W2117439999 @default.
• W2093842115 cites W2122321550 @default.
• W2093842115 cites W2125931566 @default.
• W2093842115 cites W4242171500 @default.
• W2093842115 doi "https://doi.org/10.3109/03008207.2014.906408" @default.
• W2093842115 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4098772" @default.
• W2093842115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24649870" @default.
• W2093842115 hasPublicationYear "2014" @default.
• W2093842115 type Work @default.
• W2093842115 sameAs 2093842115 @default.
• W2093842115 citedByCount "21" @default.
• W2093842115 countsByYear W20938421152015 @default.
• W2093842115 countsByYear W20938421152017 @default.
• W2093842115 countsByYear W20938421152018 @default.
• W2093842115 countsByYear W20938421152019 @default.
• W2093842115 countsByYear W20938421152020 @default.
• W2093842115 countsByYear W20938421152021 @default.
• W2093842115 countsByYear W20938421152022 @default.
• W2093842115 countsByYear W20938421152023 @default.
• W2093842115 crossrefType "journal-article" @default.
• W2093842115 hasAuthorship W2093842115A5016707131 @default.
• W2093842115 hasAuthorship W2093842115A5030384497 @default.
• W2093842115 hasAuthorship W2093842115A5045010323 @default.
• W2093842115 hasAuthorship W2093842115A5060275333 @default.
• W2093842115 hasAuthorship W2093842115A5075168513 @default.
• W2093842115 hasAuthorship W2093842115A5075484607 @default.
• W2093842115 hasAuthorship W2093842115A5081705219 @default.
• W2093842115 hasAuthorship W2093842115A5085115078 @default.
• W2093842115 hasBestOaLocation W20938421152 @default.
• W2093842115 hasConcept C126322002 @default.
• W2093842115 hasConcept C141071460 @default.
• W2093842115 hasConcept C142724271 @default.
• W2093842115 hasConcept C149892131 @default.
• W2093842115 hasConcept C170493617 @default.
• W2093842115 hasConcept C2776885963 @default.
• W2093842115 hasConcept C2776914184 @default.
• W2093842115 hasConcept C2778096516 @default.
• W2093842115 hasConcept C2778122271 @default.
• W2093842115 hasConcept C2778690821 @default.
• W2093842115 hasConcept C2779753412 @default.
• W2093842115 hasConcept C71924100 @default.
• W2093842115 hasConcept C74172505 @default.
• W2093842115 hasConceptScore W2093842115C126322002 @default.
• W2093842115 hasConceptScore W2093842115C141071460 @default.
• W2093842115 hasConceptScore W2093842115C142724271 @default.
• W2093842115 hasConceptScore W2093842115C149892131 @default.
• W2093842115 hasConceptScore W2093842115C170493617 @default.
• W2093842115 hasConceptScore W2093842115C2776885963 @default.
• W2093842115 hasConceptScore W2093842115C2776914184 @default.
• W2093842115 hasConceptScore W2093842115C2778096516 @default.
• W2093842115 hasConceptScore W2093842115C2778122271 @default.
• W2093842115 hasConceptScore W2093842115C2778690821 @default.
• W2093842115 hasConceptScore W2093842115C2779753412 @default.
• W2093842115 hasConceptScore W2093842115C71924100 @default.
• W2093842115 hasConceptScore W2093842115C74172505 @default.
• W2093842115 hasIssue "3" @default.
• W2093842115 hasLocation W20938421151 @default.
• W2093842115 hasLocation W20938421152 @default.

• next