Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093844006> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2093844006 endingPage "208" @default.
- W2093844006 startingPage "198" @default.
- W2093844006 abstract "BB rats are prone to develop an autoimmune form of insulin-dependent diabetes mellitus (IDDM) and thyroiditis. Development of autoimmunity is thymus dependent. Previous studies have shown that BB rats lack a population of T cells bearing the RT6 antigen and have very low numbers of suppressor/cytotoxic T cells. In this study, we confirm that BB rats have decreased numbers of phenotypic T suppressor/cytotoxic (Ts/c) cells (OX19+, OX8+ cells) in their lymphoid organs. Moreover, we find that the phenotypic Ts/c cells of BB rats lack apparent cytotoxic activity. These T cells fail to kill allogeneic target cells in a cell-mediated lympholysis assay and fail to generate lectin-dependent cytotoxicity. The addition of interleukin 2, gamma-interferon, and other lymphokines to cultures of BB T cells does not induce functional cytotoxic T lymphocytes. We find that the activated T cells of newly diabetic rats are incapable of killing major-histocompatibility-complex-matched islet cells, despite the ability of these cells to cause IDDM in passive transfer experiments. We conclude that autoimmune disease occurs in BB rats in the absence of functional cytotoxic T cells." @default.
- W2093844006 created "2016-06-24" @default.
- W2093844006 creator A5002335294 @default.
- W2093844006 creator A5032149753 @default.
- W2093844006 creator A5060746715 @default.
- W2093844006 creator A5063368372 @default.
- W2093844006 creator A5074700845 @default.
- W2093844006 date "1988-06-01" @default.
- W2093844006 modified "2023-10-14" @default.
- W2093844006 title "Autoimmunity-prone BB rats lack functional cytotoxic T cells" @default.
- W2093844006 cites W1529030457 @default.
- W2093844006 cites W1537796506 @default.
- W2093844006 cites W1557691522 @default.
- W2093844006 cites W1582433783 @default.
- W2093844006 cites W1595623581 @default.
- W2093844006 cites W1608468044 @default.
- W2093844006 cites W1898093192 @default.
- W2093844006 cites W1961435258 @default.
- W2093844006 cites W1979690797 @default.
- W2093844006 cites W1997671318 @default.
- W2093844006 cites W2018365777 @default.
- W2093844006 cites W2018860568 @default.
- W2093844006 cites W2029547538 @default.
- W2093844006 cites W2033700934 @default.
- W2093844006 cites W2036326377 @default.
- W2093844006 cites W2047481753 @default.
- W2093844006 cites W2047751652 @default.
- W2093844006 cites W2072086410 @default.
- W2093844006 cites W2084093106 @default.
- W2093844006 cites W2098280774 @default.
- W2093844006 cites W2161300747 @default.
- W2093844006 cites W2171932333 @default.
- W2093844006 cites W2325903650 @default.
- W2093844006 cites W4313310639 @default.
- W2093844006 doi "https://doi.org/10.1016/0008-8749(88)90266-3" @default.
- W2093844006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3131022" @default.
- W2093844006 hasPublicationYear "1988" @default.
- W2093844006 type Work @default.
- W2093844006 sameAs 2093844006 @default.
- W2093844006 citedByCount "14" @default.
- W2093844006 countsByYear W20938440062015 @default.
- W2093844006 countsByYear W20938440062021 @default.
- W2093844006 crossrefType "journal-article" @default.
- W2093844006 hasAuthorship W2093844006A5002335294 @default.
- W2093844006 hasAuthorship W2093844006A5032149753 @default.
- W2093844006 hasAuthorship W2093844006A5060746715 @default.
- W2093844006 hasAuthorship W2093844006A5063368372 @default.
- W2093844006 hasAuthorship W2093844006A5074700845 @default.
- W2093844006 hasConcept C129374314 @default.
- W2093844006 hasConcept C147483822 @default.
- W2093844006 hasConcept C154317977 @default.
- W2093844006 hasConcept C202751555 @default.
- W2093844006 hasConcept C203014093 @default.
- W2093844006 hasConcept C207936829 @default.
- W2093844006 hasConcept C2776090121 @default.
- W2093844006 hasConcept C2780130043 @default.
- W2093844006 hasConcept C49382859 @default.
- W2093844006 hasConcept C54355233 @default.
- W2093844006 hasConcept C67662055 @default.
- W2093844006 hasConcept C86803240 @default.
- W2093844006 hasConcept C8891405 @default.
- W2093844006 hasConcept C90375314 @default.
- W2093844006 hasConceptScore W2093844006C129374314 @default.
- W2093844006 hasConceptScore W2093844006C147483822 @default.
- W2093844006 hasConceptScore W2093844006C154317977 @default.
- W2093844006 hasConceptScore W2093844006C202751555 @default.
- W2093844006 hasConceptScore W2093844006C203014093 @default.
- W2093844006 hasConceptScore W2093844006C207936829 @default.
- W2093844006 hasConceptScore W2093844006C2776090121 @default.
- W2093844006 hasConceptScore W2093844006C2780130043 @default.
- W2093844006 hasConceptScore W2093844006C49382859 @default.
- W2093844006 hasConceptScore W2093844006C54355233 @default.
- W2093844006 hasConceptScore W2093844006C67662055 @default.
- W2093844006 hasConceptScore W2093844006C86803240 @default.
- W2093844006 hasConceptScore W2093844006C8891405 @default.
- W2093844006 hasConceptScore W2093844006C90375314 @default.
- W2093844006 hasIssue "1" @default.
- W2093844006 hasLocation W20938440061 @default.
- W2093844006 hasLocation W20938440062 @default.
- W2093844006 hasOpenAccess W2093844006 @default.
- W2093844006 hasPrimaryLocation W20938440061 @default.
- W2093844006 hasRelatedWork W1618908972 @default.
- W2093844006 hasRelatedWork W1969022237 @default.
- W2093844006 hasRelatedWork W1971278368 @default.
- W2093844006 hasRelatedWork W1973122969 @default.
- W2093844006 hasRelatedWork W2008057646 @default.
- W2093844006 hasRelatedWork W2025106625 @default.
- W2093844006 hasRelatedWork W2041730127 @default.
- W2093844006 hasRelatedWork W2148785609 @default.
- W2093844006 hasRelatedWork W32399917 @default.
- W2093844006 hasRelatedWork W4210976760 @default.
- W2093844006 hasVolume "114" @default.
- W2093844006 isParatext "false" @default.
- W2093844006 isRetracted "false" @default.
- W2093844006 magId "2093844006" @default.
- W2093844006 workType "article" @default.