FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093846710> ?p ?o ?g. }

• W2093846710 endingPage "433" @default.
• W2093846710 startingPage "433" @default.
• W2093846710 abstract "To the Editor.—Thrombotic thrombocytopenic purpura (TTP) is an uncommon disorder, classified as a thrombotic microangiopathy (TMA) based on clinical findings of hemolytic anemia, thrombocytopenia, neurologic symptoms, fever, and renal dysfunction.1 Unfortunately, several other TMAs have similar features (typical and atypical hemolytic uremic syndromes, disseminated intravascular coagulation, among others). An assay of ADAMTS13 is useful for distinguishing TTP from the other TMA disorders, thus identifying those patients who will benefit from plasma exchange (PE).2Barrows and Teruya3 reported their institution's experience using the ADAMTS13 assay, confirming that the test correctly identifies appropriate patients for PE. However, even with an in-house assay available, it may take hours to days to determine the ADAMTS13 result. Even that brief delay in making or refuting a diagnosis of TTP may be unacceptable to most physicians because urgent PE is the appropriate therapy.There are 2 solutions to this problem. One option is to subject all patients suspected of having TTP to PE until the ADAMTS13 result returns; however, that approach means that most patients who receive PE will be unnecessarily treated. More important, appropriate treatment for the underlying TMA disorder will be delayed. Another approach that we use at our institution is the establishment of clinical criteria for rapidly identifying patients who have a high probability, intermediate probability, or low probability of TTP.4 This clinical prediction score uses easily obtainable laboratory results (platelet count, d-dimer, creatinine, reticulocyte count, indirect bilirubin). Patients with a very low likelihood of TTP are not given PE, and alternative diagnoses are considered in those patients. Patients with an intermediate or a high likelihood of having TTP should receive PE. Results of this clinical prediction score were validated in a second cohort of patients with TMA.5We agree with Barrows and Teruya that ADAMTS13 testing is useful in diagnosing TTP. However, we disagree that “… the presence of thrombocytopenia and hemolytic anemia are generally sufficient for starting empiric treatment with TPE.”(p548) Patients with TTP represent only a few of the patients with TMA (5% in the authors' study, 10% in our studies), so exclusion of patients without TTP from receiving PE improves the efficiency of PE use and appropriate TMA management." @default.
• W2093846710 created "2016-06-24" @default.
• W2093846710 creator A5002698865 @default.
• W2093846710 creator A5021473614 @default.
• W2093846710 date "2015-04-01" @default.
• W2093846710 modified "2023-10-18" @default.
• W2093846710 title "Utility of ADAMTS13 Assays in Diagnosing Thrombotic Thrombocytopenic Purpura" @default.
• W2093846710 cites W1958251332 @default.
• W2093846710 cites W1969804753 @default.
• W2093846710 cites W2058493731 @default.
• W2093846710 cites W2083318092 @default.
• W2093846710 cites W2399974484 @default.
• W2093846710 doi "https://doi.org/10.5858/arpa.2014-0225-le" @default.
• W2093846710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25822759" @default.
• W2093846710 hasPublicationYear "2015" @default.
• W2093846710 type Work @default.
• W2093846710 sameAs 2093846710 @default.
• W2093846710 citedByCount "0" @default.
• W2093846710 crossrefType "journal-article" @default.
• W2093846710 hasAuthorship W2093846710A5002698865 @default.
• W2093846710 hasAuthorship W2093846710A5021473614 @default.
• W2093846710 hasBestOaLocation W20938467101 @default.
• W2093846710 hasConcept C126322002 @default.
• W2093846710 hasConcept C2776175824 @default.
• W2093846710 hasConcept C2777878052 @default.
• W2093846710 hasConcept C2778585876 @default.
• W2093846710 hasConcept C2778734968 @default.
• W2093846710 hasConcept C2779134260 @default.
• W2093846710 hasConcept C2780306776 @default.
• W2093846710 hasConcept C2780921031 @default.
• W2093846710 hasConcept C2781127562 @default.
• W2093846710 hasConcept C65245452 @default.
• W2093846710 hasConcept C71924100 @default.
• W2093846710 hasConcept C89560881 @default.
• W2093846710 hasConcept C90924648 @default.
• W2093846710 hasConceptScore W2093846710C126322002 @default.
• W2093846710 hasConceptScore W2093846710C2776175824 @default.
• W2093846710 hasConceptScore W2093846710C2777878052 @default.
• W2093846710 hasConceptScore W2093846710C2778585876 @default.
• W2093846710 hasConceptScore W2093846710C2778734968 @default.
• W2093846710 hasConceptScore W2093846710C2779134260 @default.
• W2093846710 hasConceptScore W2093846710C2780306776 @default.
• W2093846710 hasConceptScore W2093846710C2780921031 @default.
• W2093846710 hasConceptScore W2093846710C2781127562 @default.
• W2093846710 hasConceptScore W2093846710C65245452 @default.
• W2093846710 hasConceptScore W2093846710C71924100 @default.
• W2093846710 hasConceptScore W2093846710C89560881 @default.
• W2093846710 hasConceptScore W2093846710C90924648 @default.
• W2093846710 hasIssue "4" @default.
• W2093846710 hasLocation W20938467101 @default.
• W2093846710 hasLocation W20938467102 @default.
• W2093846710 hasOpenAccess W2093846710 @default.
• W2093846710 hasPrimaryLocation W20938467101 @default.
• W2093846710 hasRelatedWork W117349356 @default.
• W2093846710 hasRelatedWork W2246395889 @default.
• W2093846710 hasRelatedWork W2573742095 @default.
• W2093846710 hasRelatedWork W2606358287 @default.
• W2093846710 hasRelatedWork W2769821511 @default.
• W2093846710 hasRelatedWork W2804249452 @default.
• W2093846710 hasRelatedWork W2805630869 @default.
• W2093846710 hasRelatedWork W2973244740 @default.
• W2093846710 hasRelatedWork W3030402421 @default.
• W2093846710 hasRelatedWork W3134222282 @default.
• W2093846710 hasVolume "139" @default.
• W2093846710 isParatext "false" @default.
• W2093846710 isRetracted "false" @default.
• W2093846710 magId "2093846710" @default.
• W2093846710 workType "article" @default.