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• W2093846844 abstract "The future of industrial biotechnology requires efficient development of highly productive and robust strains of microorganisms. Present praxis of strain development cannot adequately fulfill this requirement, primarily owing to the inability to control reactions precisely at a molecular level, or to predict reliably the behavior of cells upon perturbation. Recent developments in two areas of biology are changing the situation rapidly: structural biology has revealed details about enzymes and associated bioreactions at an atomic level; and synthetic biology has provided tools to design and assemble precisely controllable modules for re-programming cellular metabolic circuitry. However, because of different emphases, to date, these two areas have developed separately. A linkage between them is desirable to harness their concerted potential. We therefore propose structural synthetic biotechnology as a new field in biotechnology, specifically for application to the development of industrial microbial strains. The future of industrial biotechnology requires efficient development of highly productive and robust strains of microorganisms. Present praxis of strain development cannot adequately fulfill this requirement, primarily owing to the inability to control reactions precisely at a molecular level, or to predict reliably the behavior of cells upon perturbation. Recent developments in two areas of biology are changing the situation rapidly: structural biology has revealed details about enzymes and associated bioreactions at an atomic level; and synthetic biology has provided tools to design and assemble precisely controllable modules for re-programming cellular metabolic circuitry. However, because of different emphases, to date, these two areas have developed separately. A linkage between them is desirable to harness their concerted potential. We therefore propose structural synthetic biotechnology as a new field in biotechnology, specifically for application to the development of industrial microbial strains." @default.
• W2093846844 created "2016-06-24" @default.
• W2093846844 creator A5075797131 @default.
• W2093846844 creator A5087631945 @default.
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• W2093846844 date "2010-10-01" @default.
• W2093846844 modified "2023-10-01" @default.
• W2093846844 title "Structural synthetic biotechnology: from molecular structure to predictable design for industrial strain development" @default.
• W2093846844 cites W1852364512 @default.
• W2093846844 cites W1963724731 @default.
• W2093846844 cites W1967937234 @default.
• W2093846844 cites W1970762019 @default.
• W2093846844 cites W1971951387 @default.
• W2093846844 cites W1972306691 @default.
• W2093846844 cites W1975530165 @default.
• W2093846844 cites W1978119727 @default.
• W2093846844 cites W1984248485 @default.
• W2093846844 cites W1987696643 @default.
• W2093846844 cites W1989061197 @default.
• W2093846844 cites W1995668527 @default.
• W2093846844 cites W1996320633 @default.
• W2093846844 cites W1997704539 @default.
• W2093846844 cites W1999404678 @default.
• W2093846844 cites W2002452896 @default.
• W2093846844 cites W2003788979 @default.
• W2093846844 cites W2005474992 @default.
• W2093846844 cites W2008472371 @default.
• W2093846844 cites W2009123297 @default.
• W2093846844 cites W2010222073 @default.
• W2093846844 cites W2013726100 @default.
• W2093846844 cites W2014904991 @default.
• W2093846844 cites W2015144453 @default.
• W2093846844 cites W2015492208 @default.
• W2093846844 cites W2016385245 @default.
• W2093846844 cites W2016902544 @default.
• W2093846844 cites W2018532552 @default.
• W2093846844 cites W2020652110 @default.
• W2093846844 cites W2023279102 @default.
• W2093846844 cites W2024818202 @default.
• W2093846844 cites W2027309027 @default.
• W2093846844 cites W2027578508 @default.
• W2093846844 cites W2033236457 @default.
• W2093846844 cites W2035247831 @default.
• W2093846844 cites W2036658481 @default.
• W2093846844 cites W2037380364 @default.
• W2093846844 cites W2038421716 @default.
• W2093846844 cites W2045787860 @default.
• W2093846844 cites W2046847085 @default.
• W2093846844 cites W2047015012 @default.
• W2093846844 cites W2048209665 @default.
• W2093846844 cites W2053717739 @default.
• W2093846844 cites W2056435762 @default.
• W2093846844 cites W2060098509 @default.
• W2093846844 cites W2061287541 @default.
• W2093846844 cites W2066089342 @default.
• W2093846844 cites W2067330392 @default.
• W2093846844 cites W2073936141 @default.
• W2093846844 cites W2075694416 @default.
• W2093846844 cites W2080761989 @default.
• W2093846844 cites W2081231176 @default.
• W2093846844 cites W2081475517 @default.
• W2093846844 cites W2082260955 @default.
• W2093846844 cites W2088820058 @default.
• W2093846844 cites W2091917976 @default.
• W2093846844 cites W2092006899 @default.
• W2093846844 cites W2092471565 @default.
• W2093846844 cites W2092889971 @default.
• W2093846844 cites W2095753590 @default.
• W2093846844 cites W2096358531 @default.
• W2093846844 cites W2096648003 @default.
• W2093846844 cites W2101893285 @default.
• W2093846844 cites W2104219710 @default.
• W2093846844 cites W2114047137 @default.
• W2093846844 cites W2116102379 @default.
• W2093846844 cites W2116965666 @default.
• W2093846844 cites W2132851824 @default.
• W2093846844 cites W2134759124 @default.
• W2093846844 cites W2136536485 @default.
• W2093846844 cites W2143980500 @default.
• W2093846844 cites W2146967862 @default.
• W2093846844 cites W2147516046 @default.
• W2093846844 cites W2147654860 @default.
• W2093846844 cites W2149202606 @default.
• W2093846844 cites W2150088285 @default.
• W2093846844 cites W2151457629 @default.
• W2093846844 cites W2152662598 @default.
• W2093846844 cites W2152854378 @default.
• W2093846844 cites W2169346156 @default.
• W2093846844 cites W2169408159 @default.
• W2093846844 cites W2169989540 @default.
• W2093846844 cites W2294703791 @default.
• W2093846844 cites W2616139473 @default.
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• W2093846844 doi "https://doi.org/10.1016/j.tibtech.2010.07.004" @default.
• W2093846844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20727604" @default.
• W2093846844 hasPublicationYear "2010" @default.
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