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- W2093849900 abstract "The development of drugs for poor-prognosis childhood cancers remains challenging despite many advances in the specialty. New drugs targeting specific molecular aberrations in the patients' tumours are becoming available for adult cancers and proving successful even in early stages of development. For many years, paediatric oncologists have hoped similar achievements could be seen in children and adolescents with cancer, but little success has been noted to date. Safety and activity of crizotinib for paediatric patients with refractory solid tumours or anaplastic large-cell lymphoma: a Children's Oncology Group phase 1 consortium studyThe findings suggest that a targeted inhibitor of ALK has antitumour activity in childhood malignancies harbouring ALK translocations, particularly anaplastic large-cell lymphoma and inflammatory myofibroblastic tumours, and that further investigation in the subset of neuroblastoma harbouring known ALK oncogenic mutations is warranted. Full-Text PDF" @default.
- W2093849900 created "2016-06-24" @default.
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- W2093849900 date "2013-05-01" @default.
- W2093849900 modified "2023-09-27" @default.
- W2093849900 title "ALK-targeted therapy for poor-prognosis childhood cancers" @default.
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- W2093849900 doi "https://doi.org/10.1016/s1470-2045(13)70123-2" @default.
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