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- W2093856768 endingPage "S403" @default.
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- W2093856768 abstract "Therapy with the tyrosine kinase inhibitor (TKI) represents the current standard first-line therapy for the management of patients with chronic myeloid leukemia (CML). Although most patients respond satisfactorily to imatinib, a subset of patients develops resistance mainly because of the acquisition of mutations within the kinase domain of BCR-ABL1 that impair the ability of TKIs to block the activity of the enzyme. Moreover, BCR-ABL1 transcripts can be detected in most patients by molecular techniques, underscoring the limitations of imatinib to eradicate minimal residual disease. Although the resistance conferred by most BCR-ABL1 mutations can be overcome with the use of second-generation TKIs such as nilotinib, dasastinib, bosutinib, or bafetinib, the T315I mutation, which represents a common resistance pathway in CML, remains unassailable to TKI therapy. We herein discuss current research efforts in 2 areas of vital importance in CML research, the management of patients with imatinib-resistant mutations, with particular emphasis on those carrying T315I, and the eradication of residual disease." @default.
- W2093856768 created "2016-06-24" @default.
- W2093856768 creator A5015101485 @default.
- W2093856768 creator A5019337932 @default.
- W2093856768 date "2009-12-01" @default.
- W2093856768 modified "2023-10-15" @default.
- W2093856768 title "The Next Generation of Therapies for Chronic Myeloid Leukemia" @default.
- W2093856768 cites W1482758361 @default.
- W2093856768 cites W1965615377 @default.
- W2093856768 cites W1971879465 @default.
- W2093856768 cites W1973363947 @default.
- W2093856768 cites W1973720500 @default.
- W2093856768 cites W1975748957 @default.
- W2093856768 cites W1979107490 @default.
- W2093856768 cites W1981083415 @default.
- W2093856768 cites W1981631249 @default.
- W2093856768 cites W1987239635 @default.
- W2093856768 cites W1988464631 @default.
- W2093856768 cites W1992244448 @default.
- W2093856768 cites W1994309500 @default.
- W2093856768 cites W1996490450 @default.
- W2093856768 cites W1999614615 @default.
- W2093856768 cites W2003973314 @default.
- W2093856768 cites W2005515343 @default.
- W2093856768 cites W2015616444 @default.
- W2093856768 cites W2016086822 @default.
- W2093856768 cites W2017881524 @default.
- W2093856768 cites W2023569481 @default.
- W2093856768 cites W2038120084 @default.
- W2093856768 cites W2041004587 @default.
- W2093856768 cites W2043789128 @default.
- W2093856768 cites W2048258225 @default.
- W2093856768 cites W2051465464 @default.
- W2093856768 cites W2053356355 @default.
- W2093856768 cites W2054251966 @default.
- W2093856768 cites W2054640472 @default.
- W2093856768 cites W2057718276 @default.
- W2093856768 cites W2059568372 @default.
- W2093856768 cites W2066099870 @default.
- W2093856768 cites W2066998725 @default.
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- W2093856768 cites W2093616162 @default.
- W2093856768 cites W2095745765 @default.
- W2093856768 cites W2097177625 @default.
- W2093856768 cites W2097946794 @default.
- W2093856768 cites W2100451270 @default.
- W2093856768 cites W2101390452 @default.
- W2093856768 cites W2105214030 @default.
- W2093856768 cites W2107268345 @default.
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- W2093856768 cites W2123772306 @default.
- W2093856768 cites W2124196948 @default.
- W2093856768 cites W2126129237 @default.
- W2093856768 cites W2129901357 @default.
- W2093856768 cites W2131174104 @default.
- W2093856768 cites W2134566943 @default.
- W2093856768 cites W2136284645 @default.
- W2093856768 cites W2139226937 @default.
- W2093856768 cites W2143877481 @default.
- W2093856768 cites W2147618576 @default.
- W2093856768 cites W2148743957 @default.
- W2093856768 cites W2149468947 @default.
- W2093856768 cites W2150703483 @default.
- W2093856768 cites W2151445954 @default.
- W2093856768 cites W2152713204 @default.
- W2093856768 cites W2157369898 @default.
- W2093856768 cites W2159863363 @default.
- W2093856768 cites W2163892366 @default.
- W2093856768 cites W2312804644 @default.
- W2093856768 cites W2485410755 @default.
- W2093856768 cites W2530253091 @default.
- W2093856768 cites W2538709448 @default.
- W2093856768 cites W2553742303 @default.
- W2093856768 cites W2563314792 @default.
- W2093856768 cites W2565606062 @default.
- W2093856768 cites W2580147791 @default.
- W2093856768 cites W2582791630 @default.
- W2093856768 cites W2588203581 @default.
- W2093856768 cites W2593776441 @default.
- W2093856768 cites W2612051898 @default.
- W2093856768 cites W2980038641 @default.
- W2093856768 cites W4234479229 @default.
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- W2093856768 doi "https://doi.org/10.3816/clm.2009.s.040" @default.
- W2093856768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20007109" @default.
- W2093856768 hasPublicationYear "2009" @default.
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