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• W2093862317 abstract "Abstract Growing evidence from in vitro studies suggests that spinal serotonin (5‐HT) receptor subtypes 5‐HTR 1A and 5‐HTR 7 are associated with an induction of central pattern generator activity. However, the possibility of a specific role for these receptor subtypes in locomotor rhythmogenesis in vivo remains unclear. Here, we studied the effects of a single dose (1 mg/kg, i.p.) of 8‐hydroxy‐2‐(di‐N‐propylamino)‐tetralin (8‐OH‐DPAT), a potent and selective 5‐HTR 1A/7 agonist, in mice spinal cord transected at the low‐thoracic level (Th9/10). The results show that 8‐OH‐DPAT acutely induced, within 15 min, hindlimb movements that share some characteristics with normal locomotion. Paraplegic mice pretreated with the selective 5‐HTR 1A antagonists, WAY100,135 or WAY100,635, displayed significantly less 8‐OH‐DPAT‐induced movement. A similar reduction of 8‐OH‐DPAT‐induced movements was found in animals pretreated with SB269970, a selective 5‐HTR 7 antagonist. Moreover, a near complete blockade of 8‐OH‐DPAT‐induced movement was obtained in wild‐type mice pretreated with 5‐HTR 1A and 5‐HTR 7 antagonists, and in 5‐HTR 7 –/– mice pretreated with 5‐HTR 1A antagonists. Overall, these results clearly demonstrate that 8‐OH‐DPAT potently induces locomotor‐like movement in the previously paralysed hindlimbs of low‐thoracic‐transected mice. The results, with selective antagonists and knockout animals, provide compelling evidence of a specific contribution of both receptor subtypes to spinal locomotor rhythmogenesis in vivo ." @default.
• W2093862317 created "2016-06-24" @default.
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• W2093862317 date "2006-07-01" @default.
• W2093862317 modified "2023-10-12" @default.
• W2093862317 title "Contribution of spinal 5-HT_1Aand 5-HT₇receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice" @default.
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• W2093862317 doi "https://doi.org/10.1111/j.1460-9568.2006.04917.x" @default.
• W2093862317 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16836640" @default.
• W2093862317 hasPublicationYear "2006" @default.
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