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- W2093869314 abstract "Urine from untreated patients with various tumours and controls has been examined for the excretion of β-aminoisobutyric acid and uric acid. The patients were classified into four groups: I, β-aminoisobutyric acid and uric acid both normal; II, β-aminoisobutyric acid normal, uric acid elevated; III, β-aminoisobutyric acid elevated, uric acid normal; IV, β-aminoisobutyric acid and uric acid both elevated. Uric acid was used as an indicator for tissue-breakdown. Pseudouridine being a specific parameter for t-RNA degradation was estimated for comparison. Increased urinary concentrations of β-aminoisobutyric acid were frequently found in tumour patients, especially in patients with leukaemia and non-Hodgkin lymphoma. Tissue breakdown being the cause of the β-aminoisobutyric aciduria could only be considered in part of the patients. Moreover, strongly elevated ratios of β-aminoisobutyric acid to uric acid were found. Urinary patterns of pyrimidines and purines were determined in order to exclude other abnormalities. The results are discussed in relation to thymine metabolism and renal function." @default.
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- W2093869314 date "1987-06-01" @default.
- W2093869314 modified "2023-10-17" @default.
- W2093869314 title "β-Aminoisobutyric acid as a marker of thymine catabolism in malignancy" @default.
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- W2093869314 doi "https://doi.org/10.1016/0009-8981(87)90182-3" @default.
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