FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093880979> ?p ?o ?g. }

• W2093880979 endingPage "94" @default.
• W2093880979 startingPage "82" @default.
• W2093880979 abstract "We used a photochemical method to generate a partial ischemic injury to the infraorbital branch of the trigeminal nerve in rats. Following injury, rats developed a bilateral persistent hypersensitivity to mechanical stimulation in the territory innervated by the infraorbital nerve. In addition, spread of mechanical hypersensitivity beyond the facial region was noted. Heat hypersensitivity was also present, although to a lesser extent and of a shorter duration. In some rats, excessive facial grooming/scratching were observed. Morphological examination revealed a graded damage to the irradiated portion of the infraorbital nerve that was related to the duration of laser irradiation. Investigations of gene expression changes in injured trigeminal ganglion neurons of animals with behavioral signs of neuropathic pain demonstrated that the sodium channel α-subunit Nav1.3—absent in sham-operated animals—was expressed to a limited extent. mRNAs for Nav1.8 and Nav1.9 were reduced both with respect to proportions of expressing neurons and to intensities, whereas the β3 subunit was markedly upregulated. mRNA levels of p11, a regulatory factor that facilitates the surface expression of Nav1.8, were unchanged. Previous findings have shown that injury to the trigeminal nerve branches may elicit responses that differ from those of segmental spinal nerves. Despite this we conclude that the key sodium channel regulations that are reported as consequences of nerve damage in the dorsal root ganglia seem to appear also in the trigeminal ganglion. Thus, novel analgesic drugs designed to target the sodium channel subtypes involved could be of use for the treatment of orofacial pain." @default.
• W2093880979 created "2016-06-24" @default.
• W2093880979 creator A5004909473 @default.
• W2093880979 creator A5019700436 @default.
• W2093880979 creator A5050969311 @default.
• W2093880979 creator A5055926195 @default.
• W2093880979 creator A5056388603 @default.
• W2093880979 creator A5057481020 @default.
• W2093880979 creator A5070426496 @default.
• W2093880979 creator A5083230589 @default.
• W2093880979 date "2005-12-01" @default.
• W2093880979 modified "2023-10-07" @default.
• W2093880979 title "Behavioral changes and trigeminal ganglion sodium channel regulation in an orofacial neuropathic pain model" @default.
• W2093880979 cites W1527531631 @default.
• W2093880979 cites W1910213480 @default.
• W2093880979 cites W1959152155 @default.
• W2093880979 cites W2000574545 @default.
• W2093880979 cites W2008465842 @default.
• W2093880979 cites W2013128693 @default.
• W2093880979 cites W2017357594 @default.
• W2093880979 cites W2018481729 @default.
• W2093880979 cites W2018965901 @default.
• W2093880979 cites W2023771303 @default.
• W2093880979 cites W2024788984 @default.
• W2093880979 cites W2033001509 @default.
• W2093880979 cites W2041857602 @default.
• W2093880979 cites W2062176870 @default.
• W2093880979 cites W2067924690 @default.
• W2093880979 cites W2071595010 @default.
• W2093880979 cites W2071862338 @default.
• W2093880979 cites W2074263579 @default.
• W2093880979 cites W2075316492 @default.
• W2093880979 cites W2075634263 @default.
• W2093880979 cites W2079688458 @default.
• W2093880979 cites W2079692119 @default.
• W2093880979 cites W2105498897 @default.
• W2093880979 cites W2115713486 @default.
• W2093880979 cites W2117963590 @default.
• W2093880979 cites W2118555930 @default.
• W2093880979 doi "https://doi.org/10.1016/j.pain.2005.09.019" @default.
• W2093880979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16297558" @default.
• W2093880979 hasPublicationYear "2005" @default.
• W2093880979 type Work @default.
• W2093880979 sameAs 2093880979 @default.
• W2093880979 citedByCount "50" @default.
• W2093880979 countsByYear W20938809792012 @default.
• W2093880979 countsByYear W20938809792013 @default.
• W2093880979 countsByYear W20938809792014 @default.
• W2093880979 countsByYear W20938809792015 @default.
• W2093880979 countsByYear W20938809792016 @default.
• W2093880979 countsByYear W20938809792017 @default.
• W2093880979 countsByYear W20938809792019 @default.
• W2093880979 countsByYear W20938809792020 @default.
• W2093880979 countsByYear W20938809792021 @default.
• W2093880979 countsByYear W20938809792022 @default.
• W2093880979 countsByYear W20938809792023 @default.
• W2093880979 crossrefType "journal-article" @default.
• W2093880979 hasAuthorship W2093880979A5004909473 @default.
• W2093880979 hasAuthorship W2093880979A5019700436 @default.
• W2093880979 hasAuthorship W2093880979A5050969311 @default.
• W2093880979 hasAuthorship W2093880979A5055926195 @default.
• W2093880979 hasAuthorship W2093880979A5056388603 @default.
• W2093880979 hasAuthorship W2093880979A5057481020 @default.
• W2093880979 hasAuthorship W2093880979A5070426496 @default.
• W2093880979 hasAuthorship W2093880979A5083230589 @default.
• W2093880979 hasConcept C105702510 @default.
• W2093880979 hasConcept C126322002 @default.
• W2093880979 hasConcept C140530291 @default.
• W2093880979 hasConcept C141071460 @default.
• W2093880979 hasConcept C15744967 @default.
• W2093880979 hasConcept C169760540 @default.
• W2093880979 hasConcept C178790620 @default.
• W2093880979 hasConcept C185592680 @default.
• W2093880979 hasConcept C24998067 @default.
• W2093880979 hasConcept C2775991916 @default.
• W2093880979 hasConcept C2776281502 @default.
• W2093880979 hasConcept C2776352249 @default.
• W2093880979 hasConcept C2777107010 @default.
• W2093880979 hasConcept C2777397368 @default.
• W2093880979 hasConcept C2780767800 @default.
• W2093880979 hasConcept C2781334511 @default.
• W2093880979 hasConcept C2781463296 @default.
• W2093880979 hasConcept C42219234 @default.
• W2093880979 hasConcept C50952357 @default.
• W2093880979 hasConcept C537181965 @default.
• W2093880979 hasConcept C71924100 @default.
• W2093880979 hasConcept C94487597 @default.
• W2093880979 hasConceptScore W2093880979C105702510 @default.
• W2093880979 hasConceptScore W2093880979C126322002 @default.
• W2093880979 hasConceptScore W2093880979C140530291 @default.
• W2093880979 hasConceptScore W2093880979C141071460 @default.
• W2093880979 hasConceptScore W2093880979C15744967 @default.
• W2093880979 hasConceptScore W2093880979C169760540 @default.
• W2093880979 hasConceptScore W2093880979C178790620 @default.
• W2093880979 hasConceptScore W2093880979C185592680 @default.
• W2093880979 hasConceptScore W2093880979C24998067 @default.
• W2093880979 hasConceptScore W2093880979C2775991916 @default.
• W2093880979 hasConceptScore W2093880979C2776281502 @default.

• next