Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093886458> ?p ?o ?g. }
- W2093886458 endingPage "42" @default.
- W2093886458 startingPage "36" @default.
- W2093886458 abstract "Summary Prostaglandin E 2 (PGE 2 ), a major lipid derived from the metabolism of arachidonic acid, is an environmentally bioactive substance produced by inflammatory processes and acts as a cAMP up‐regulator that plays an important role in immune responses. It has been reported that PGE 2 has the ability to inhibit the production of interleukin‐12 by myeloid dendritic cells (MDCs) and macrophages, and then induce preferential T helper type 2 (Th2) cell responses. However, little is known of the function of PGE 2 for plasmacytoid dendritic cells (PDCs), which may contribute to the innate and adaptive immune response to viral infection, allergy and autoimmune diseases. In the present study, we compared the biological effect of PGE 2 on human PDCs and MDCs. PGE 2 caused the death of PDCs but MDCs survived. Furthermore, we found that, whereas PGE 2 inhibited interferon‐α production by PDCs in response to virus or cytosine–phosphate–guanosine, it inhibited interelukin‐12 production by MDCs in response to lipopolysaccharide (LPS) or poly(I:C). Although both virus‐stimulated PDCs and LPS‐stimulated MDCs preferentially induced the development of interferon‐γ‐producing Th1 cells, pretreatment with PGE 2 led both DC subsets to attenuate their Th1‐inducing capacity. These findings suggest that PGE 2 represents a negative regulator on not only MDCs but also PDCs." @default.
- W2093886458 created "2016-06-24" @default.
- W2093886458 creator A5002284882 @default.
- W2093886458 creator A5005318923 @default.
- W2093886458 creator A5013230999 @default.
- W2093886458 creator A5025418725 @default.
- W2093886458 creator A5028875915 @default.
- W2093886458 creator A5034172526 @default.
- W2093886458 creator A5042785140 @default.
- W2093886458 creator A5070616465 @default.
- W2093886458 creator A5076008841 @default.
- W2093886458 date "2006-06-06" @default.
- W2093886458 modified "2023-10-15" @default.
- W2093886458 title "Prostaglandin E2 is a negative regulator on human plasmacytoid dendritic cells" @default.
- W2093886458 cites W1517310071 @default.
- W2093886458 cites W1568945049 @default.
- W2093886458 cites W1601925808 @default.
- W2093886458 cites W1603866561 @default.
- W2093886458 cites W1661544713 @default.
- W2093886458 cites W1743787976 @default.
- W2093886458 cites W1769928764 @default.
- W2093886458 cites W1967562647 @default.
- W2093886458 cites W1981746803 @default.
- W2093886458 cites W1986315531 @default.
- W2093886458 cites W1991524518 @default.
- W2093886458 cites W2000768335 @default.
- W2093886458 cites W2007503046 @default.
- W2093886458 cites W2021786991 @default.
- W2093886458 cites W2031078224 @default.
- W2093886458 cites W2033172475 @default.
- W2093886458 cites W2033828670 @default.
- W2093886458 cites W2062350041 @default.
- W2093886458 cites W2065907531 @default.
- W2093886458 cites W2066013154 @default.
- W2093886458 cites W2067989244 @default.
- W2093886458 cites W2072696221 @default.
- W2093886458 cites W2099648364 @default.
- W2093886458 cites W2099938481 @default.
- W2093886458 cites W2104904748 @default.
- W2093886458 cites W2106566281 @default.
- W2093886458 cites W2111220263 @default.
- W2093886458 cites W2114833834 @default.
- W2093886458 cites W2116716017 @default.
- W2093886458 cites W2119162416 @default.
- W2093886458 cites W2121444779 @default.
- W2093886458 cites W2122643628 @default.
- W2093886458 cites W2123190790 @default.
- W2093886458 cites W2126043069 @default.
- W2093886458 cites W2129943043 @default.
- W2093886458 cites W2135110049 @default.
- W2093886458 cites W2137083667 @default.
- W2093886458 cites W2150753841 @default.
- W2093886458 cites W2151809081 @default.
- W2093886458 cites W2155391532 @default.
- W2093886458 cites W2157898241 @default.
- W2093886458 cites W2159075850 @default.
- W2093886458 cites W2160739580 @default.
- W2093886458 cites W2167366928 @default.
- W2093886458 cites W2169758620 @default.
- W2093886458 cites W2177327503 @default.
- W2093886458 doi "https://doi.org/10.1111/j.1365-2567.2006.02402.x" @default.
- W2093886458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1782338" @default.
- W2093886458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16762028" @default.
- W2093886458 hasPublicationYear "2006" @default.
- W2093886458 type Work @default.
- W2093886458 sameAs 2093886458 @default.
- W2093886458 citedByCount "35" @default.
- W2093886458 countsByYear W20938864582012 @default.
- W2093886458 countsByYear W20938864582013 @default.
- W2093886458 countsByYear W20938864582014 @default.
- W2093886458 countsByYear W20938864582020 @default.
- W2093886458 countsByYear W20938864582021 @default.
- W2093886458 countsByYear W20938864582022 @default.
- W2093886458 countsByYear W20938864582023 @default.
- W2093886458 crossrefType "journal-article" @default.
- W2093886458 hasAuthorship W2093886458A5002284882 @default.
- W2093886458 hasAuthorship W2093886458A5005318923 @default.
- W2093886458 hasAuthorship W2093886458A5013230999 @default.
- W2093886458 hasAuthorship W2093886458A5025418725 @default.
- W2093886458 hasAuthorship W2093886458A5028875915 @default.
- W2093886458 hasAuthorship W2093886458A5034172526 @default.
- W2093886458 hasAuthorship W2093886458A5042785140 @default.
- W2093886458 hasAuthorship W2093886458A5070616465 @default.
- W2093886458 hasAuthorship W2093886458A5076008841 @default.
- W2093886458 hasBestOaLocation W20938864581 @default.
- W2093886458 hasConcept C104317684 @default.
- W2093886458 hasConcept C134018914 @default.
- W2093886458 hasConcept C185592680 @default.
- W2093886458 hasConcept C187316574 @default.
- W2093886458 hasConcept C203014093 @default.
- W2093886458 hasConcept C2776051438 @default.
- W2093886458 hasConcept C2776178377 @default.
- W2093886458 hasConcept C2777198256 @default.
- W2093886458 hasConcept C2777956040 @default.
- W2093886458 hasConcept C2778170410 @default.
- W2093886458 hasConcept C2778754761 @default.
- W2093886458 hasConcept C55493867 @default.
- W2093886458 hasConcept C6929976 @default.