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• W2093889144 startingPage "10096" @default.
• W2093889144 abstract "ABSTRACT Several primate models indicate that cytotoxic T lymphocyte-inducing vaccines may be unable to prevent human immunodeficiency virus infection but may have a long-term benefit in controlling viral replication and delaying disease progression. Here we show that analysis of the kinetics of antigen-specific CD8 + T-cell expansion suggests a delay in activation following infection that allows unimpeded early viral replication. Viral kinetics do not differ between controls and vaccinees during this delay phase. An increase in virus-specific CD8 + T-cell numbers around day 10 postinfection coincides with a slowing in viral replication in vaccinees and reduces peak viral loads by around 1 log. However, this response is too little too late to prevent establishment of persistent infection." @default.
• W2093889144 created "2016-06-24" @default.
• W2093889144 creator A5006896785 @default.
• W2093889144 creator A5033826368 @default.
• W2093889144 creator A5058338534 @default.
• W2093889144 date "2004-09-15" @default.
• W2093889144 modified "2023-09-26" @default.
• W2093889144 title "Kinetics of Virus-Specific CD8 ⁺ T Cells and the Control of Human Immunodeficiency Virus Infection" @default.
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• W2093889144 doi "https://doi.org/10.1128/jvi.78.18.10096-10103.2004" @default.
• W2093889144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/515020" @default.
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