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- W2093889596 abstract "Beef heart extracts purified by adsorption on Al(OH)3 were assayed in terms of I-adrenaline and I-noradrenaline on cat's blood pressure, hen's rectal caecum and rat's non-pregnant uterus. Using the hen's rectal caecum in conjunction with the cat's blood pressure as a test preparation, the biological assay of heart extract was found to contain 8 % to 20 % adrenaline and 92 % to 74 % noradrenaline. The auricle extracts showed 8 % to 11 % adrenaline while the ventricle extracts gave 16.6 % to 26 % adrenaline. The heart extract had an antagonistic effect upon the response of the hen's rectal caecum to adrenaline and noradrenaline. This inhibition of the adrenaline and noradrenaline was usually more marked in the case of adrenaline. Further the ratio of adrenaline to noradrenaline was generally altered after the use of cardiac extract. Using the method of paper chromatography, the heart extract produced three distinct spots. These were adrenaline, noradrenaline and an unknown factor. All three spots were separately laked and the resulting three substances were biologically assayed. The unknown spot had the same inhibitory effect upon adrenaline and noradrenaline in the rectal caecum as did the original heart extract. The noradrenaline and adrenaline spot corresponded to pure solutions of these substances." @default.
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- W2093889596 date "1950-08-01" @default.
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- W2093889596 title "The Presence of Noradrenaline, Adrenaline, and an Unknown Sympatliicolytic Factor in Cattle Heart" @default.
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- W2093889596 doi "https://doi.org/10.1111/j.1748-1716.1950.tb00692.x" @default.
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