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• W2093896324 abstract "Acid-sensing ion channels (ASICs) are ion channels activated by extracellular protons. They are involved in higher brain functions and perception of pain, taste, and mechanical stimuli. Homomeric ASIC1a is potently inhibited by the tarantula toxin psalmotoxin 1. The mechanism of this inhibition is unknown. Here we show that psalmotoxin 1 inhibits ASIC1a by a unique mechanism: the toxin increases the apparent affinity for H(+) of ASIC1a. Since ASIC1a is activated by H(+) concentrations that are only slightly larger than the resting H(+) concentration, this increase in H(+) affinity is sufficient to shift ASIC1a channels into the desensitized state. As activation of ASIC1a has recently been linked to neurodegeneration associated with stroke, our results suggest chronic desensitization of ASIC1a by a slight increase of its H(+) affinity as a possible way of therapeutic intervention in stroke." @default.
• W2093896324 created "2016-06-24" @default.
• W2093896324 creator A5053098849 @default.
• W2093896324 creator A5053982692 @default.
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• W2093896324 date "2005-06-13" @default.
• W2093896324 modified "2023-10-12" @default.
• W2093896324 title "The Tarantula Toxin Psalmotoxin 1 Inhibits Acid-sensing Ion Channel (ASIC) 1a by Increasing Its Apparent H+ Affinity" @default.
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• W2093896324 doi "https://doi.org/10.1085/jgp.200509303" @default.
• W2093896324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2266618" @default.
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