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- W2093899400 abstract "Ischemia-reperfusion (I/R) injury is one of the risk factors for delayed graft function, acute rejection episodes, and impaired long-term allograft survival after kidney transplantation. This antigen-independent inflammatory process produces tissue damage. Isogeneic transplantation in a rat model is a useful method for study of nonimmunologic risk factors for kidney damage. To study the effect of sirolimus on I/R injury using only 1 dose of the drug in the donor. Eighteen rats were allocated to 3 groups of 6 rats each: sham group, control group, and rapamycin group. Improved renal function and systemic inflammatory response were observed in the rapamycin group compared with the control group (Δurea, Δcreatinine, and ΔC3, all P < .01). The number of apoptotic nuclei in the renal medulla in the control group was higher than in the rapamycin group ( P < .01). Tubular damage was less severe in the rapamycin group compared with the control group ( P < .01). Complement 3 and tumor necrosis factor-α expression in the kidney samples were significantly decreased when rapamycin was given to the donor rats ( P > .01). Bcl-2 protein was upregulated in the rapamycin group compared with the control group ( P < .01). Administration of rapamycin in donors attenuates the I/R injury process after kidney transplantation in a rat model." @default.
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- W2093899400 date "2010-01-01" @default.
- W2093899400 modified "2023-09-26" @default.
- W2093899400 title "Sirolimus in Kidney Transplant Donors and Clinical and Histologic Improvement in Recipients: Rat Model" @default.
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- W2093899400 doi "https://doi.org/10.1016/j.transproceed.2009.11.013" @default.
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