Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093908258> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2093908258 endingPage "S44" @default.
- W2093908258 startingPage "S44" @default.
- W2093908258 abstract "A novel Na+ / H+ exchanger-1 (NHE-1) inhibitor [5-(2-methoxy-5-chloro-5-phenyl)furan-2-ylcarbonyl]guanidine (KR-32570) has been previously demonstrated to elicit cardioprotective effect against ischemic injury in rat heart. In the present study, we examined the effects of KR-32570 on cell death induced by hypoxic insult in heart-derived H9c2 cells. Treatment with KR-32570 (1–10 μM) significantly reduced hypoxia-induced necrotic cell death (lactate dehydrogenase release) and apoptotic cell death (TUNEL-positivity, caspase-3 activity). KR-32570 also decreased the cytosolic and mitochondrial Ca2+ overload induced by hypoxia. Inhibition of mitochondrial Ca2+ overload by ruthenium red mimicked the anti-apoptotic effect of KR-32570. In addition, KR-32570 significantly recovered the large reduction in mitochondrial membrane potential (ΔΨm) and cytochrome c release induced by hypoxia. Taken together, our results suggest that a new NHE-1 inhibitor KR-32570 elicits potent cardioprotective effects in H9c2 cells, and its effects may be mediated by inhibition of intracellular Ca2+ overload and mitochondrial death pathway during hypoxia." @default.
- W2093908258 created "2016-06-24" @default.
- W2093908258 creator A5004301430 @default.
- W2093908258 creator A5021116902 @default.
- W2093908258 creator A5028285045 @default.
- W2093908258 creator A5074447030 @default.
- W2093908258 date "2011-09-01" @default.
- W2093908258 modified "2023-10-16" @default.
- W2093908258 title "Activation of Nuclear Factor-kappaB by doxorubicin leads to inhibition of extrinsic pathway of apoptosis in H9c2 cells" @default.
- W2093908258 doi "https://doi.org/10.1016/j.clinbiochem.2011.08.1065" @default.
- W2093908258 hasPublicationYear "2011" @default.
- W2093908258 type Work @default.
- W2093908258 sameAs 2093908258 @default.
- W2093908258 citedByCount "0" @default.
- W2093908258 crossrefType "journal-article" @default.
- W2093908258 hasAuthorship W2093908258A5004301430 @default.
- W2093908258 hasAuthorship W2093908258A5021116902 @default.
- W2093908258 hasAuthorship W2093908258A5028285045 @default.
- W2093908258 hasAuthorship W2093908258A5074447030 @default.
- W2093908258 hasConcept C153911025 @default.
- W2093908258 hasConcept C178790620 @default.
- W2093908258 hasConcept C181199279 @default.
- W2093908258 hasConcept C185592680 @default.
- W2093908258 hasConcept C190283241 @default.
- W2093908258 hasConcept C196795494 @default.
- W2093908258 hasConcept C2777318727 @default.
- W2093908258 hasConcept C28859421 @default.
- W2093908258 hasConcept C29311851 @default.
- W2093908258 hasConcept C31573885 @default.
- W2093908258 hasConcept C540031477 @default.
- W2093908258 hasConcept C55493867 @default.
- W2093908258 hasConcept C7836513 @default.
- W2093908258 hasConcept C79879829 @default.
- W2093908258 hasConcept C86803240 @default.
- W2093908258 hasConcept C95444343 @default.
- W2093908258 hasConcept C98274493 @default.
- W2093908258 hasConcept C98424977 @default.
- W2093908258 hasConcept C98539663 @default.
- W2093908258 hasConceptScore W2093908258C153911025 @default.
- W2093908258 hasConceptScore W2093908258C178790620 @default.
- W2093908258 hasConceptScore W2093908258C181199279 @default.
- W2093908258 hasConceptScore W2093908258C185592680 @default.
- W2093908258 hasConceptScore W2093908258C190283241 @default.
- W2093908258 hasConceptScore W2093908258C196795494 @default.
- W2093908258 hasConceptScore W2093908258C2777318727 @default.
- W2093908258 hasConceptScore W2093908258C28859421 @default.
- W2093908258 hasConceptScore W2093908258C29311851 @default.
- W2093908258 hasConceptScore W2093908258C31573885 @default.
- W2093908258 hasConceptScore W2093908258C540031477 @default.
- W2093908258 hasConceptScore W2093908258C55493867 @default.
- W2093908258 hasConceptScore W2093908258C7836513 @default.
- W2093908258 hasConceptScore W2093908258C79879829 @default.
- W2093908258 hasConceptScore W2093908258C86803240 @default.
- W2093908258 hasConceptScore W2093908258C95444343 @default.
- W2093908258 hasConceptScore W2093908258C98274493 @default.
- W2093908258 hasConceptScore W2093908258C98424977 @default.
- W2093908258 hasConceptScore W2093908258C98539663 @default.
- W2093908258 hasIssue "13" @default.
- W2093908258 hasLocation W20939082581 @default.
- W2093908258 hasOpenAccess W2093908258 @default.
- W2093908258 hasPrimaryLocation W20939082581 @default.
- W2093908258 hasRelatedWork W1967012492 @default.
- W2093908258 hasRelatedWork W19916217 @default.
- W2093908258 hasRelatedWork W2000225649 @default.
- W2093908258 hasRelatedWork W2036667953 @default.
- W2093908258 hasRelatedWork W2366219004 @default.
- W2093908258 hasRelatedWork W2383263084 @default.
- W2093908258 hasRelatedWork W2389329888 @default.
- W2093908258 hasRelatedWork W2399613612 @default.
- W2093908258 hasRelatedWork W3046665064 @default.
- W2093908258 hasRelatedWork W75757574 @default.
- W2093908258 hasVolume "44" @default.
- W2093908258 isParatext "false" @default.
- W2093908258 isRetracted "false" @default.
- W2093908258 magId "2093908258" @default.
- W2093908258 workType "article" @default.