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• W2093915828 abstract "The potent cholesterol absorption inhibitor ezetimibe was developed as a first-in-class drug for treating hypercholesterolemia even before its molecular target, Niemann–Pick C1-like 1 (NPC1L1), had been identified. The NPC1L1 protein mediates sterol transport across the enterocyte brush border membrane and is essential for intestinal cholesterol absorption, a major pathway controlling whole-body cholesterol homeostasis. An elucidation of the mechanism underlying NPC1L1-dependent cholesterol absorption would greatly facilitate the discovery and development of new cholesterol-lowering agents for treating hypercholesterolemia and other cholesterol-related metabolic disorders. Clinical Pharmacology & Therapeutics (2010) 87 1, 117–121. doi:10.1038/clpt.2009.209" @default.
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• W2093915828 date "2009-11-11" @default.
• W2093915828 modified "2023-10-16" @default.
• W2093915828 title "Transporters as Drug Targets: Discovery and Development of NPC1L1 Inhibitors" @default.
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• W2093915828 doi "https://doi.org/10.1038/clpt.2009.209" @default.
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