Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093916547> ?p ?o ?g. }
- W2093916547 endingPage "e1631" @default.
- W2093916547 startingPage "e1631" @default.
- W2093916547 abstract "Abstract The intestinal mucosa undergoes a continual process of proliferation, differentiation and apoptosis, which is regulated by multiple signaling pathways. Notch signaling is critical for the control of intestinal stem cell maintenance and differentiation. However, the precise mechanisms involved in the regulation of differentiation are not fully understood. Previously, we have shown that tuberous sclerosis 2 (TSC2) positively regulates the expression of the goblet cell differentiation marker, MUC2, in intestinal cells. Using transgenic mice constitutively expressing a dominant negative TSC2 allele, we observed that TSC2 inactivation increased mTORC1 and Notch activities, and altered differentiation throughout the intestinal epithelium, with a marked decrease in the goblet and Paneth cell lineages. Conversely, treatment of mice with either Notch inhibitor dibenzazepine (DBZ) or mTORC1 inhibitor rapamycin significantly attenuated the reduction of goblet and Paneth cells. Accordingly, knockdown of TSC2 activated, whereas knockdown of mTOR or treatment with rapamycin decreased, the activity of Notch signaling in the intestinal cell line LS174T. Importantly, our findings demonstrate that TSC2/mTORC1 signaling contributes to the maintenance of intestinal epithelium homeostasis by regulating Notch activity." @default.
- W2093916547 created "2016-06-24" @default.
- W2093916547 creator A5002622543 @default.
- W2093916547 creator A5023436882 @default.
- W2093916547 creator A5049763932 @default.
- W2093916547 creator A5066347342 @default.
- W2093916547 creator A5068753759 @default.
- W2093916547 date "2015-02-05" @default.
- W2093916547 modified "2023-10-06" @default.
- W2093916547 title "TSC2/mTORC1 signaling controls Paneth and goblet cell differentiation in the intestinal epithelium" @default.
- W2093916547 cites W1533468810 @default.
- W2093916547 cites W1568038787 @default.
- W2093916547 cites W1569826023 @default.
- W2093916547 cites W1579159557 @default.
- W2093916547 cites W1964566687 @default.
- W2093916547 cites W1967998205 @default.
- W2093916547 cites W1976753789 @default.
- W2093916547 cites W1977962361 @default.
- W2093916547 cites W1978091144 @default.
- W2093916547 cites W1983829192 @default.
- W2093916547 cites W1990442683 @default.
- W2093916547 cites W1997582221 @default.
- W2093916547 cites W1999804745 @default.
- W2093916547 cites W2011239505 @default.
- W2093916547 cites W2012448969 @default.
- W2093916547 cites W2012632470 @default.
- W2093916547 cites W2013617388 @default.
- W2093916547 cites W2025819729 @default.
- W2093916547 cites W2029810183 @default.
- W2093916547 cites W2031435441 @default.
- W2093916547 cites W2042283565 @default.
- W2093916547 cites W2061745177 @default.
- W2093916547 cites W2062150443 @default.
- W2093916547 cites W2068129356 @default.
- W2093916547 cites W2069107251 @default.
- W2093916547 cites W2069636292 @default.
- W2093916547 cites W2076852872 @default.
- W2093916547 cites W2080100938 @default.
- W2093916547 cites W2086313707 @default.
- W2093916547 cites W2087524781 @default.
- W2093916547 cites W2087812126 @default.
- W2093916547 cites W2088651611 @default.
- W2093916547 cites W2089371363 @default.
- W2093916547 cites W2089778901 @default.
- W2093916547 cites W2096579470 @default.
- W2093916547 cites W2104136706 @default.
- W2093916547 cites W2107162587 @default.
- W2093916547 cites W2108213314 @default.
- W2093916547 cites W2111214065 @default.
- W2093916547 cites W2111304119 @default.
- W2093916547 cites W2113486346 @default.
- W2093916547 cites W2117159794 @default.
- W2093916547 cites W2119573240 @default.
- W2093916547 cites W2121208012 @default.
- W2093916547 cites W2127063807 @default.
- W2093916547 cites W2127539789 @default.
- W2093916547 cites W2130396048 @default.
- W2093916547 cites W2133475958 @default.
- W2093916547 cites W2136662222 @default.
- W2093916547 cites W2139095510 @default.
- W2093916547 cites W2159599443 @default.
- W2093916547 cites W2159664830 @default.
- W2093916547 cites W2163382569 @default.
- W2093916547 cites W2166802510 @default.
- W2093916547 cites W2167862372 @default.
- W2093916547 cites W4210953366 @default.
- W2093916547 cites W4212793614 @default.
- W2093916547 doi "https://doi.org/10.1038/cddis.2014.588" @default.
- W2093916547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4669793" @default.
- W2093916547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25654764" @default.
- W2093916547 hasPublicationYear "2015" @default.
- W2093916547 type Work @default.
- W2093916547 sameAs 2093916547 @default.
- W2093916547 citedByCount "53" @default.
- W2093916547 countsByYear W20939165472015 @default.
- W2093916547 countsByYear W20939165472016 @default.
- W2093916547 countsByYear W20939165472017 @default.
- W2093916547 countsByYear W20939165472018 @default.
- W2093916547 countsByYear W20939165472019 @default.
- W2093916547 countsByYear W20939165472020 @default.
- W2093916547 countsByYear W20939165472021 @default.
- W2093916547 countsByYear W20939165472022 @default.
- W2093916547 countsByYear W20939165472023 @default.
- W2093916547 crossrefType "journal-article" @default.
- W2093916547 hasAuthorship W2093916547A5002622543 @default.
- W2093916547 hasAuthorship W2093916547A5023436882 @default.
- W2093916547 hasAuthorship W2093916547A5049763932 @default.
- W2093916547 hasAuthorship W2093916547A5066347342 @default.
- W2093916547 hasAuthorship W2093916547A5068753759 @default.
- W2093916547 hasBestOaLocation W20939165471 @default.
- W2093916547 hasConcept C104317684 @default.
- W2093916547 hasConcept C126322002 @default.
- W2093916547 hasConcept C134018914 @default.
- W2093916547 hasConcept C148738053 @default.
- W2093916547 hasConcept C150194340 @default.
- W2093916547 hasConcept C161879069 @default.
- W2093916547 hasConcept C2775941134 @default.
- W2093916547 hasConcept C2776145723 @default.