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- W2093916615 abstract "Les histiocytoses langerhansiennes sont des pathologies rares englobant un large spectre de maladies aux manifestations très variées. Le traitement, parfois difficile, est fonction de l'évolution et de l'extension de la maladie. Nous rapportons le cas d'une femme de 33 ans porteuse d'une histiocytose langerhansienne avec atteintes osseuses et vulvaire dont les lésions cutanéomuqueuses résistant aux traitements habituels ont été améliorées de manière spectaculaire après un traitement par thalidomide, sans effet secondaire clinique ou électrophysiologique. L'arrêt du traitement du fait d'une somnolence s'accompagne d'une récidive en moins de 2 semaines. Un contrôle complet est de nouveau obtenu après reprise du thalidomide. La simplicité d'emploi du thalidomide et son effet rapide sur les lésions cutanées d'histiocytoses langerhansiennes devraient conduire à une nouvelle évaluation clinique de ce traitement déjà ancien. De plus, cette molécule reste utile chez certains patients atteints de maladies systémiques dont l'atteinte cutanéomuqueuse échappe aux thérapeutiques habituelles. Langerhans cell histiocytosis is a rare disorder with a wide spectrum of diseases and various clinical behaviours. The prognosis depends on the patient's age at onset and the extension of the disease. Treatment is function of evolution and extension of the disease. We report one case of Langerhans cell histiocytosis in a 33-year-old woman with resistant vulvar involvement whose cutaneous lesions improved with thalidomide. Complete healing of the genital lesions occurred within 1 month, but the patient discontinued her treatment after 3 months because of somnolence. Recurrence of the symptoms was observed within 2 weeks without treatment, but complete control was obtained with reintroduction of thalidomide. No severe adverse effect was detected at electrophysiological and clinical examinations. The simplicity and the rapid effect of thalidomide on cutaneous lesions suggest that new clinical evaluation of this old drug that can also be used in some systemic disease might be of the value." @default.
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- W2093916615 date "1998-03-01" @default.
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- W2093916615 title "Histiocytose langerhansienne de l'adulte: localisations cutanéomuqueuses régressives après traitement par thalidomide" @default.
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- W2093916615 doi "https://doi.org/10.1016/s0248-8663(97)80720-5" @default.
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