FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093933183> ?p ?o ?g. }

• W2093933183 endingPage "112" @default.
• W2093933183 startingPage "99" @default.
• W2093933183 abstract "A typical clinical cis-diamminedichloroplatinum(II) (cisplatin) dosing regimen consists of repeated treatment cycles followed by a recovery period. While effective, this dosing structure results in a prolonged, often permanent, infertility in men. Spermatogonial stem cells (SSCs) are theoretically capable of repopulating the seminiferous tubules after exposure has ceased. We propose that an altered spermatogonial environment during recovery from the initial treatment cycle drives an increase in SSC mitotic cell activity, rendering the SSC pool increasingly susceptible to cisplatin-induced injury from subsequent cycles. To test this hypothesis, the undifferentiated spermatogonia population and niche of the adult mouse (C57/BL/6J) were examined during the recovery periods of a clinically-relevant cisplatin exposure paradigm. Histological examination revealed a disorganization of spermatogenesis correlating with the number of exposure cycles. Quantification of terminal deoxynucleotidyl transferase-mediated digoxigenin-dUTP nick end labeling (TUNEL) staining indicated an increase in apoptotic frequency following exposure. Immunohistochemical examination of Foxo1 and incorporated BrdU showed an increase in the undifferentiated spermatogonial population and mitotic activity in the recovery period in mice exposed to one cycle, but not two cycles of cisplatin. Immunohistochemical investigation of glial cell line-derived neurotrophic factor (GDNF) revealed an increase in production along the basal Sertoli cell membrane throughout the recovery period in all treatment groups. Taken together, these data establish that the impact of cisplatin exposure on the functional stem cell pool and niche correlates with: (1) the number of dosing cycles; (2) mitotic activity of early germ cells; and (3) alterations in the basal Sertoli cell GDNF expression levels after cisplatin-induced testicular injury." @default.
• W2093933183 created "2016-06-24" @default.
• W2093933183 creator A5005788391 @default.
• W2093933183 creator A5037145387 @default.
• W2093933183 date "2014-06-01" @default.
• W2093933183 modified "2023-09-28" @default.
• W2093933183 title "Cisplatin-induced alterations in the functional spermatogonial stem cell pool and niche in C57/BL/6J mice following a clinically relevant multi-cycle exposure" @default.
• W2093933183 cites W1501307527 @default.
• W2093933183 cites W1516316082 @default.
• W2093933183 cites W1550251645 @default.
• W2093933183 cites W1559909070 @default.
• W2093933183 cites W1762711869 @default.
• W2093933183 cites W1861752925 @default.
• W2093933183 cites W1974053385 @default.
• W2093933183 cites W1986149669 @default.
• W2093933183 cites W1988557854 @default.
• W2093933183 cites W1996236446 @default.
• W2093933183 cites W1997765083 @default.
• W2093933183 cites W1997919787 @default.
• W2093933183 cites W2003473161 @default.
• W2093933183 cites W2008561807 @default.
• W2093933183 cites W2008605395 @default.
• W2093933183 cites W2009944870 @default.
• W2093933183 cites W2014657344 @default.
• W2093933183 cites W2021397187 @default.
• W2093933183 cites W2026777536 @default.
• W2093933183 cites W2032630894 @default.
• W2093933183 cites W2037979286 @default.
• W2093933183 cites W2041426853 @default.
• W2093933183 cites W2043637071 @default.
• W2093933183 cites W2043851579 @default.
• W2093933183 cites W2064446194 @default.
• W2093933183 cites W2085671699 @default.
• W2093933183 cites W2087435869 @default.
• W2093933183 cites W2088612857 @default.
• W2093933183 cites W2090997970 @default.
• W2093933183 cites W2094898025 @default.
• W2093933183 cites W2104457965 @default.
• W2093933183 cites W2117680234 @default.
• W2093933183 cites W2122716764 @default.
• W2093933183 cites W2126318561 @default.
• W2093933183 cites W2130177169 @default.
• W2093933183 cites W2131202983 @default.
• W2093933183 cites W2140563146 @default.
• W2093933183 cites W2144134929 @default.
• W2093933183 cites W2144679570 @default.
• W2093933183 cites W2147898515 @default.
• W2093933183 cites W2151201243 @default.
• W2093933183 cites W2151623295 @default.
• W2093933183 cites W2154108142 @default.
• W2093933183 cites W2157822813 @default.
• W2093933183 cites W2163846802 @default.
• W2093933183 cites W2166384143 @default.
• W2093933183 cites W2168003742 @default.
• W2093933183 cites W2171929902 @default.
• W2093933183 cites W2846525165 @default.
• W2093933183 doi "https://doi.org/10.1016/j.toxlet.2014.03.019" @default.
• W2093933183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4041011" @default.
• W2093933183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24704392" @default.
• W2093933183 hasPublicationYear "2014" @default.
• W2093933183 type Work @default.
• W2093933183 sameAs 2093933183 @default.
• W2093933183 citedByCount "20" @default.
• W2093933183 countsByYear W20939331832015 @default.
• W2093933183 countsByYear W20939331832016 @default.
• W2093933183 countsByYear W20939331832017 @default.
• W2093933183 countsByYear W20939331832018 @default.
• W2093933183 countsByYear W20939331832019 @default.
• W2093933183 countsByYear W20939331832020 @default.
• W2093933183 countsByYear W20939331832021 @default.
• W2093933183 countsByYear W20939331832023 @default.
• W2093933183 crossrefType "journal-article" @default.
• W2093933183 hasAuthorship W2093933183A5005788391 @default.
• W2093933183 hasAuthorship W2093933183A5037145387 @default.
• W2093933183 hasBestOaLocation W20939331832 @default.
• W2093933183 hasConcept C104317684 @default.
• W2093933183 hasConcept C123765429 @default.
• W2093933183 hasConcept C126322002 @default.
• W2093933183 hasConcept C134018914 @default.
• W2093933183 hasConcept C160539049 @default.
• W2093933183 hasConcept C16685009 @default.
• W2093933183 hasConcept C170493617 @default.
• W2093933183 hasConcept C185856081 @default.
• W2093933183 hasConcept C190283241 @default.
• W2093933183 hasConcept C2776694085 @default.
• W2093933183 hasConcept C2778239845 @default.
• W2093933183 hasConcept C2779122487 @default.
• W2093933183 hasConcept C2781068068 @default.
• W2093933183 hasConcept C28328180 @default.
• W2093933183 hasConcept C2908647359 @default.
• W2093933183 hasConcept C29537977 @default.
• W2093933183 hasConcept C54355233 @default.
• W2093933183 hasConcept C71924100 @default.
• W2093933183 hasConcept C86803240 @default.
• W2093933183 hasConcept C95444343 @default.
• W2093933183 hasConcept C99454951 @default.
• W2093933183 hasConceptScore W2093933183C104317684 @default.
• W2093933183 hasConceptScore W2093933183C123765429 @default.

• next