Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093942039> ?p ?o ?g. }
- W2093942039 endingPage "69" @default.
- W2093942039 startingPage "63" @default.
- W2093942039 abstract "We evaluated the effects of NT-702 (parogrelil hydrochloride, NM-702, 4-bromo-6-[3-(4-chlorophenyl) propoxy]-5-[(pyridine-3-ylmethyl) amino] pyridazin-3(2H)-one hydrochloride), a selective phosphodiesterase 3 inhibitor, on the asthmatic response in guinea pigs. NT-702 at a concentration of 1 x 10(-7)M elevated the cyclic adenosine monophosphate content in prostaglandin E(2)-treated guinea pig tracheal smooth muscle cells. Leukotriene (LT) D(4)- and histamine-induced contraction of isolated guinea pig tracheal strips was inhibited by NT-702, with EC(50) values of 3.2 x 10(-7) and 2.5 x 10(-7)M, respectively. In an in vivo study, NT-702 suppressed LTD(4)-induced bronchoconstriction and the ovalbumin-induced immediate asthmatic response in guinea pigs through its bronchodilating effect. Furthermore, NT-702 also suppressed the ovalbumin-induced late asthmatic response, airway hyperresponsiveness, and the accumulation of inflammatory cells in the bronchoalveolar lavage fluid. These results suggest that NT-702 has an anti-inflammatory effect as well as a bronchodilating effect and might be useful as a novel potent therapeutic agent for the treatment of bronchial asthma, a new type of agent with both a bronchodilating and an anti-inflammatory effect." @default.
- W2093942039 created "2016-06-24" @default.
- W2093942039 creator A5002265537 @default.
- W2093942039 creator A5004756806 @default.
- W2093942039 creator A5005472418 @default.
- W2093942039 creator A5005966536 @default.
- W2093942039 creator A5012663409 @default.
- W2093942039 creator A5027999029 @default.
- W2093942039 creator A5053784133 @default.
- W2093942039 creator A5059267775 @default.
- W2093942039 creator A5060179161 @default.
- W2093942039 creator A5074303746 @default.
- W2093942039 date "2009-09-01" @default.
- W2093942039 modified "2023-09-27" @default.
- W2093942039 title "NT-702 (parogrelil hydrochloride, NM-702), a novel and potent phosphodiesterase 3 inhibitor, suppress the asthmatic response in guinea pigs, with both bronchodilating and anti-inflammatory effects" @default.
- W2093942039 cites W1485478348 @default.
- W2093942039 cites W1738497100 @default.
- W2093942039 cites W1932738671 @default.
- W2093942039 cites W1964151709 @default.
- W2093942039 cites W1964897436 @default.
- W2093942039 cites W1966135492 @default.
- W2093942039 cites W1966337309 @default.
- W2093942039 cites W1973793029 @default.
- W2093942039 cites W1984062113 @default.
- W2093942039 cites W1984534195 @default.
- W2093942039 cites W1990002876 @default.
- W2093942039 cites W1991163844 @default.
- W2093942039 cites W1991177887 @default.
- W2093942039 cites W1994226794 @default.
- W2093942039 cites W1995642722 @default.
- W2093942039 cites W2004177921 @default.
- W2093942039 cites W2012564197 @default.
- W2093942039 cites W2013407710 @default.
- W2093942039 cites W2021620212 @default.
- W2093942039 cites W2027001724 @default.
- W2093942039 cites W2044045740 @default.
- W2093942039 cites W2045739339 @default.
- W2093942039 cites W2070286718 @default.
- W2093942039 cites W2081323519 @default.
- W2093942039 cites W2087968375 @default.
- W2093942039 cites W2091549165 @default.
- W2093942039 cites W2096223487 @default.
- W2093942039 cites W2125087832 @default.
- W2093942039 cites W2127853200 @default.
- W2093942039 cites W2133369375 @default.
- W2093942039 cites W2141412402 @default.
- W2093942039 cites W2142889758 @default.
- W2093942039 cites W2143868803 @default.
- W2093942039 cites W2169790351 @default.
- W2093942039 cites W2192928034 @default.
- W2093942039 cites W4234800119 @default.
- W2093942039 doi "https://doi.org/10.1016/j.ejphar.2009.07.005" @default.
- W2093942039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19616537" @default.
- W2093942039 hasPublicationYear "2009" @default.
- W2093942039 type Work @default.
- W2093942039 sameAs 2093942039 @default.
- W2093942039 citedByCount "7" @default.
- W2093942039 countsByYear W20939420392012 @default.
- W2093942039 countsByYear W20939420392017 @default.
- W2093942039 countsByYear W20939420392019 @default.
- W2093942039 countsByYear W20939420392020 @default.
- W2093942039 countsByYear W20939420392023 @default.
- W2093942039 crossrefType "journal-article" @default.
- W2093942039 hasAuthorship W2093942039A5002265537 @default.
- W2093942039 hasAuthorship W2093942039A5004756806 @default.
- W2093942039 hasAuthorship W2093942039A5005472418 @default.
- W2093942039 hasAuthorship W2093942039A5005966536 @default.
- W2093942039 hasAuthorship W2093942039A5012663409 @default.
- W2093942039 hasAuthorship W2093942039A5027999029 @default.
- W2093942039 hasAuthorship W2093942039A5053784133 @default.
- W2093942039 hasAuthorship W2093942039A5059267775 @default.
- W2093942039 hasAuthorship W2093942039A5060179161 @default.
- W2093942039 hasAuthorship W2093942039A5074303746 @default.
- W2093942039 hasConcept C1122143 @default.
- W2093942039 hasConcept C126322002 @default.
- W2093942039 hasConcept C134018914 @default.
- W2093942039 hasConcept C181199279 @default.
- W2093942039 hasConcept C185592680 @default.
- W2093942039 hasConcept C203014093 @default.
- W2093942039 hasConcept C2776042228 @default.
- W2093942039 hasConcept C2776178081 @default.
- W2093942039 hasConcept C2776238763 @default.
- W2093942039 hasConcept C2776460385 @default.
- W2093942039 hasConcept C2776766087 @default.
- W2093942039 hasConcept C2776946954 @default.
- W2093942039 hasConcept C2777714996 @default.
- W2093942039 hasConcept C2777961210 @default.
- W2093942039 hasConcept C2778815084 @default.
- W2093942039 hasConcept C2780769369 @default.
- W2093942039 hasConcept C2781018748 @default.
- W2093942039 hasConcept C55493867 @default.
- W2093942039 hasConcept C62826618 @default.
- W2093942039 hasConcept C71924100 @default.
- W2093942039 hasConcept C8891405 @default.
- W2093942039 hasConcept C98274493 @default.
- W2093942039 hasConceptScore W2093942039C1122143 @default.
- W2093942039 hasConceptScore W2093942039C126322002 @default.
- W2093942039 hasConceptScore W2093942039C134018914 @default.