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- W2093951746 abstract "An efficient and divergent methodology for the synthesis of new anthracenone-pyranones and anthracenone-furans is described. Key reactions discussed in these syntheses include an aldehyde promoted annulation with a β-keto-sulfoxide, a domino alkyne insertion/carbonylation/Nu-acylation and a DMEDA promoted Castro-Stephens reaction. We also report the in vitro growth inhibition of these compounds in a range of human cancer cells. The natural product BE-26554A displayed good cell growth activity on BE2-C neuroblastoma and SMA glioblastoma cell lines at 0.17 and 0.16μM (GI50), respectively. Of note, were a CF3 functionalised anthracenone 4-pyranone (chromone) derivative 22, and an anthracenone-furan derivative 54 which displayed 0.20μM and 0.38μM growth inhibition, respectively, in the BE2-C neuroblastoma cell line." @default.
- W2093951746 created "2016-06-24" @default.
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- W2093951746 date "2015-07-01" @default.
- W2093951746 modified "2023-09-25" @default.
- W2093951746 title "The synthesis and biological activity of novel anthracenone-pyranones and anthracenone-furans" @default.
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- W2093951746 doi "https://doi.org/10.1016/j.bmc.2015.04.032" @default.
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