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- W2093959857 abstract "Molecules isolated from target tissues of various neuronal populations have been shown to enable the survival of those innervating neurones. A molecule derived from bovine heart which can support the survival of parasympathetic neurones of the chick embryo ciliary ganglion in vitro has been sequenced and identified as a member of the class 1 heparin binding growth factors (HBGF-1). When injected into developing chick embryos during the period of naturally occurring cell death in the ciliary ganglion, HBGF-1 failed to rescue those neurones which normally die. There was, however, a premature increase in the activity of choline acetyltransferase within the ganglion and a shift to the right in the size distribution of the neurones. We conclude that HBGF-1 may promote the differentiation of some subpopulation of neurones of the ciliary ganglion of the chick embryo but does not act in vivo as a survival molecule." @default.
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- W2093959857 date "1991-11-01" @default.
- W2093959857 modified "2023-09-25" @default.
- W2093959857 title "Class 1 heparin binding growth factor promotes the differentiation but not the survival of ciliary neurones in vivo" @default.
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- W2093959857 doi "https://doi.org/10.1016/0165-3806(91)90062-n" @default.
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