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- W2093962094 abstract "Real time Endoscopic Ultrasound Elastography (EUS-E) is a new imaging modality that characterizes abnormalities based on tissue stiffness (elasticity). Prior studies using this technology have been recently conducted in Europe and Asia aiding in the diagnosis of various gastrointestinal and pancreatic diseases. The aim of this study is to evaluate the utility of EUS-E in predicting pancreatic cancer based on quantitative analysis of tissue stiffness (Strain Ratio;SR). A linear echoendoscope (EG 3870 UTK, Pentax) was used to examine the pancreas with standard B-mode imaging (Hitachi HA 900) in 37 patients with pancreatic abnormalities. Real time tissue elastography was then applied in areas of interest displayed as a color overlay of the real-time B-mode image. Strain, a measure of elasticity, was then determined from two points: A (Area of interest); B (adjacent normal tissue). The ratio of B/A (Strain Ratio) was calculated as a quantitative measure of elasticity. Fine Needle Aspiration (FNA) was performed in all subjects with: (1) A SR in the area of interest > 25; (2) mass on B-mode EUS or (3) mass on pre-procedure imaging (CT or MRI). Cytology was performed on all the FNA specimens and presence of malignancy evaluated. Patients were considered to have benign disease if the cytology on FNA specimens did not show malignancy or if they did not develop pancreatic cancer at 12 months of clinical follow up. Thirty seven patients (13 males, 24 females, mean age 64 yrs, range 31-86) underwent EUS for evaluation of various pancreatic abnormalities (7 suspected mass on imaging, 6 obstructive jaundice, 19 chronic pancreatitis, 5 others). Sixteen out of 37 patients (43%) had cytological evidence of pancreatic cancer with a mean SR of 41.19 ± 22.36. Twenty one of 37 patients (57%) had benign disease (based on negative cytology and no development of cancer on clinical follow up) with a mean SR of 22.80 ± 28.43. The sensitivity and specificity for predicting pancreatic cancer using a strain ratio of 25 was 88% and 76% respectively. Using EUS Elastography, a Strain Ratio of 25 accurately predicted likelihood of pancreatic cancer. Further research needs to be conducted to improve the sensitivity,specificity and accurancy of predicting pancreatic cancer as well as improving cytological diagnosis using this new modality." @default.
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- W2093962094 date "2011-04-01" @default.
- W2093962094 modified "2023-10-16" @default.
- W2093962094 title "Mo1387 Does Real Time Endoscopic Ultrasound Elastography (EUS-E) Predict Pancreatic Cancer?" @default.
- W2093962094 doi "https://doi.org/10.1016/j.gie.2011.03.685" @default.
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