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- W2093963412 abstract "17β-Estradiol has been shown to induce progestin receptor synthesis in those areas of the brain which mediate sexual behavior, the mediobasal hypothalamus (MBH) and the preoptic area (POA). In this study, we explored the temporal relationship between inducible progestin receptors in both MBH-POA and pituitary and the time course of estrogen activation of mating behavior. Both mating behavior and cytosol [3H]R5020 binding in brain and pituitary increase monotonically when Silastic capsules containing 17β-estradiol are implanted and decrease monotonically when the capsules are removed. After implantation of estradiol, increases in cytosol [3H]R5020 binding are seen at 12, 24, 36, and 48 h. Receptivity is first observed at 18 h; subsequent increases in the lordosis quotient score are seen at 24, 36, and 48 h. After 48 h, inducible progestin receptors in both MBH-POA and pituitary are maximal, and sexual receptivity is approaching maximal levels. After removal of estradiol, decreases in cytosol [3H]R5020 bind..." @default.
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- W2093963412 date "1980-09-01" @default.
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- W2093963412 title "The Temporal Relationship between Estrogen-Inducible Progestin Receptors in the Female Rat Brain and the Time Course of Estrogen Activation of Mating Behavior*" @default.
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- W2093963412 doi "https://doi.org/10.1210/endo-107-3-774" @default.
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