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- W2093963792 abstract "1. 17α-Hydroperoxypregnenolone, incubated under aerobic as well as anaerobic conditions with bovine adrenal homogenates, and with 33000 × g supernatant acetone-powder preparations gave 17α-hydroxypregnenolone as the major conversion product. In addition, 3β-hydroxy-5-androsten-17-one and 5-androstene-3,17-dione, arising from scission of the acetyl side-chain, were also found. Similarly, 17a-hydroperoxypro-gesterone was reduced to the corresponding 17α-alcohol. However, in this case its expected cleavage product, 4-androstene-3,17-dione, could not as yet be ascertained a direct metabolite due to possible background interference. 2. With heat-inactivated enzyme preparations, both 17α-hydroperoxypregnenes remained unchanged. 3. The specific reduction of the 17α-hydroperoxy group was found to be inhibited by P-chloromercuribenzoate (PCMB) at a concentration of i mM, thereby revealing the true enzymatic nature of the reaction. Furthermore, time-course analysis demonstrates that the 17α-hydroperoxypregnenes are converted much faster to the known 17α-hydroxy steroid hormones, than their 17α-unsubstituted analogs. These results, obtained for the first time with mammalian enzyme sources provide further support for our hypothesis is that certain biological steroid hydroxylations may indeed proceed in two steps according to the sequence: initial peroxidation → reduction. 4. The chemical identities of the conversion products were established by the powerful technique of combined gas chromatography-mass spectrometry. Relatively important amounts of pregnenolone and 4-androstene-3,17-dione were in this way found to be present in the supernatant fractions of bovine adrenals." @default.
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- W2093963792 date "1972-04-01" @default.
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- W2093963792 title "17α-Hydroperoxypregnenes. III. Studies on their role as possible precursors in the biosynthesis of adrenosteroid hormones" @default.
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- W2093963792 doi "https://doi.org/10.1016/0005-2760(72)90022-7" @default.
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