Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093969953> ?p ?o ?g. }
- W2093969953 endingPage "728" @default.
- W2093969953 startingPage "715" @default.
- W2093969953 abstract "Proteins, due to the delicate balance of stabilizing and destabilizing interactions, are only marginally stable. Adaptation to extreme environments tends to shift the 'mesophilic' characteristics of proteins to the respective extremes of temperature, hydrostatic pressure, pH and salinity, such that, under the mutual physiological conditions, the molecular properties are similar regarding overall topology, flexibility and solvation. Enhanced intrinsic stability requires only minute local structural changes so that general strategies of stabilization cannot be established. Apart from mutative changes of amino-acid sequences, extrinsic factors (or cellular components) may be involved in 'extremophilic adaptation'. The molecular basis of acidophilic, alkalophilic and barophilic adaptation is still obscure. Mechanisms of enhanced thermal stability involve improved packing density, as well as specific local interactions. In halophiles, water and salt binding of the intrinsically stable protein inventory is accomplished by favoring acidic over basic amino acid residues and decreased hydrophobicity. General limits of viability are: (a) the susceptibility of the covalent structure of the polypeptide chain toward hydrolysis or hydrothermal degradation; (b) the competition of extreme solvent parameters with the weak electrostatic and hydrophobic interactions involved in protein stabilization; (c) perturbations of the folding and assembly of proteins; and (d) 'dislocation' of biochemical pathways due to effects of extreme conditions on the intricate network of metabolic reactions." @default.
- W2093969953 created "2016-06-24" @default.
- W2093969953 creator A5023088787 @default.
- W2093969953 date "1991-12-01" @default.
- W2093969953 modified "2023-10-09" @default.
- W2093969953 title "Protein stability and molecular adaptation to extreme conditons" @default.
- W2093969953 cites W113688923 @default.
- W2093969953 cites W1487994944 @default.
- W2093969953 cites W1496368635 @default.
- W2093969953 cites W1508614526 @default.
- W2093969953 cites W1517305271 @default.
- W2093969953 cites W1525462137 @default.
- W2093969953 cites W1529800611 @default.
- W2093969953 cites W1541258411 @default.
- W2093969953 cites W154174044 @default.
- W2093969953 cites W1543775139 @default.
- W2093969953 cites W1548617948 @default.
- W2093969953 cites W1562907760 @default.
- W2093969953 cites W1575848977 @default.
- W2093969953 cites W157808733 @default.
- W2093969953 cites W1579340188 @default.
- W2093969953 cites W171003663 @default.
- W2093969953 cites W1750817335 @default.
- W2093969953 cites W1756213192 @default.
- W2093969953 cites W187801720 @default.
- W2093969953 cites W1965703634 @default.
- W2093969953 cites W1968447293 @default.
- W2093969953 cites W1969741344 @default.
- W2093969953 cites W1973316236 @default.
- W2093969953 cites W1977196676 @default.
- W2093969953 cites W1977689824 @default.
- W2093969953 cites W1978224436 @default.
- W2093969953 cites W1979249166 @default.
- W2093969953 cites W1980022131 @default.
- W2093969953 cites W1980065107 @default.
- W2093969953 cites W1981448996 @default.
- W2093969953 cites W1984965754 @default.
- W2093969953 cites W1990466851 @default.
- W2093969953 cites W1991958052 @default.
- W2093969953 cites W1994056590 @default.
- W2093969953 cites W1994353245 @default.
- W2093969953 cites W1994574951 @default.
- W2093969953 cites W2001304403 @default.
- W2093969953 cites W2006027828 @default.
- W2093969953 cites W2006043716 @default.
- W2093969953 cites W2009292400 @default.
- W2093969953 cites W2010458167 @default.
- W2093969953 cites W2011213117 @default.
- W2093969953 cites W2012664948 @default.
- W2093969953 cites W2013414174 @default.
- W2093969953 cites W2013759002 @default.
- W2093969953 cites W2021163287 @default.
- W2093969953 cites W2022402206 @default.
- W2093969953 cites W2027027784 @default.
- W2093969953 cites W2032445880 @default.
- W2093969953 cites W2035177298 @default.
- W2093969953 cites W2035938536 @default.
- W2093969953 cites W2037729661 @default.
- W2093969953 cites W2039896604 @default.
- W2093969953 cites W2047044987 @default.
- W2093969953 cites W2049986828 @default.
- W2093969953 cites W2053483740 @default.
- W2093969953 cites W2055777918 @default.
- W2093969953 cites W2056442674 @default.
- W2093969953 cites W2056954807 @default.
- W2093969953 cites W2057443486 @default.
- W2093969953 cites W2057594216 @default.
- W2093969953 cites W2059150886 @default.
- W2093969953 cites W2060514455 @default.
- W2093969953 cites W2066558912 @default.
- W2093969953 cites W2067130595 @default.
- W2093969953 cites W2070184351 @default.
- W2093969953 cites W2070783701 @default.
- W2093969953 cites W2075970627 @default.
- W2093969953 cites W2078933151 @default.
- W2093969953 cites W2078958697 @default.
- W2093969953 cites W2080793490 @default.
- W2093969953 cites W2082657939 @default.
- W2093969953 cites W2092383329 @default.
- W2093969953 cites W2094208253 @default.
- W2093969953 cites W2095375426 @default.
- W2093969953 cites W2101347698 @default.
- W2093969953 cites W2102588957 @default.
- W2093969953 cites W2109284125 @default.
- W2093969953 cites W2110899059 @default.
- W2093969953 cites W2116173437 @default.
- W2093969953 cites W2117715668 @default.
- W2093969953 cites W2132203356 @default.
- W2093969953 cites W2133067061 @default.
- W2093969953 cites W2134051495 @default.
- W2093969953 cites W2139327615 @default.
- W2093969953 cites W2143116533 @default.
- W2093969953 cites W2143216196 @default.
- W2093969953 cites W2149315921 @default.
- W2093969953 cites W2155450902 @default.
- W2093969953 cites W2158383001 @default.
- W2093969953 cites W2161088913 @default.
- W2093969953 cites W2163575734 @default.