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- W2093972492 abstract "Development of resistance to endocrine therapy is a clinical issue in estrogen receptor (ER)-positive breast cancer. Here we show that persistent activation of AKT/mTOR signaling is crucial to the acquisition of letrozole resistance in cell clones generated from MCF-7/AROM-1 aromatase-expressing breast cancer cells after prolonged letrozole exposure. ERα plays a marginal role in this context. As a proof of concept, the association between PI3K/AKT/mTOR signaling and insensitivity to endocrine therapies was confirmed in breast cancer patients who developed early letrozole resistance in neoadjuvant setting. In addition our results suggest that, regardless of the mechanism mediating the activation of AKT/mTOR pathway, either RAD001 or NVP-BEZ235 treatment may represent a promising strategy to overcome acquired resistance to letrozole in breast cancers dependent on AKT/mTOR signaling." @default.
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- W2093972492 date "2010-11-01" @default.
- W2093972492 modified "2023-09-27" @default.
- W2093972492 title "198 Assessing the role of phosphoinositide 3-kinase (PI3K) in head and neck cancers" @default.
- W2093972492 doi "https://doi.org/10.1016/s1359-6349(10)71903-0" @default.
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