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- W2093973921 abstract "To show that the maternal hyperoxygenation test for pulmonary vascular reactivity (HPVR) is useful for prognosis in the fetus with very small lungs associated with congenital diaphragmatic hernia (CDH). Twenty four fetuses with severe CDH underwent HPVR after 30 weeks gestation. Severe CDH was defined as lung smaller than the cardiac mass in the transverse image of the fetal thorax. Doppler studies of the mid right pulmonary artery were performed before and after 10 minutes of the mother oxygenation by mask. Before and after pulsatility indices (PI) of the flow patterns were compared. A positive change was considered as a greater than 20% decrease in PI indicating increased pulmonary blood flow. Of the 24 fetuses with CDH, 12 are alive and 12 died after delivery. Of those alive, 12 of 12 (100%) had a positive HPVR. Of those who died, 8 of 12 had a negative HPVR. Of those infants who died with a positive HPVR, all underwent CDH surgical repair with Gore-Tex patch: one died at 85 days with sepsis, one who died at 60 days had meconium aspiration syndrome and respiratory failure, one died at 29 days with sepsis, and one died at 13 days from sepsis who also had single kidney and cleft palate. The maternal hyperoxygenation test for pulmonary vascular reactivity can be useful for prognosis when fetuses are found to have CDH with small lungs. Surgical expertise and experience and a dedicated neonatal extracorporeal membrane oxygenation team are required to maintain these infants." @default.
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- W2093973921 date "2005-09-01" @default.
- W2093973921 modified "2023-10-06" @default.
- W2093973921 title "OC14.04: Outcomes after the functional evaluation of fetal pulmonary vascular reactivity by the maternal hyperoxygenation test in diaphragmatic hernia" @default.
- W2093973921 doi "https://doi.org/10.1002/uog.2077" @default.
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