FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093984014> ?p ?o ?g. }

• W2093984014 endingPage "214" @default.
• W2093984014 startingPage "209" @default.
• W2093984014 abstract "In this study, we evaluated whether beta-adrenoceptor antagonists may modify the protective efficacy of dizocilpine (MK-801), a NMDA receptor antagonist, and 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466), a non-NMDA (AMPA/kainate) receptor antagonist, against maximal electroshock-induced seizures in mice. Propranolol, acebutolol, metoprolol and atenolol were used in doses that did not alter the electroconvulsive threshold. Propranolol potentiated the anticonvulsant activity of MK-801 and GYKI 52466, significantly lowering their ED(50) values from 0.38 and 15.0 to 0.15 (P<0.001) and 8.4 mg/kg (P<0.001), respectively. Similarly, metoprolol lowered the ED(50) of MK-801 and GYKI 52466 from 0.38 and 15.0 to 0.17 (P<0.05) and 11.2 mg/kg (P<0.05). Acebutolol enhanced the protective action of GYKI 52466, lowering its ED(50) value from 15.0 to 12.2 mg/kg (P<0.05), but not that of MK-801. Atenolol, not penetrating the blood-brain barrier, did not affect the anticonvulsive efficacy of MK-801 and GYKI 52466. In conclusion, beta-adrenoceptor antagonists may act synergistically with excitatory amino acid receptor antagonists to inhibit generalised tonic-clonic seizures." @default.
• W2093984014 created "2016-06-24" @default.
• W2093984014 creator A5008233161 @default.
• W2093984014 creator A5011949046 @default.
• W2093984014 creator A5023843044 @default.
• W2093984014 creator A5046320025 @default.
• W2093984014 creator A5087701130 @default.
• W2093984014 date "2001-11-01" @default.
• W2093984014 modified "2023-10-18" @default.
• W2093984014 title "β-Adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock" @default.
• W2093984014 cites W141203753 @default.
• W2093984014 cites W1487443352 @default.
• W2093984014 cites W1970138298 @default.
• W2093984014 cites W1972926571 @default.
• W2093984014 cites W1986153347 @default.
• W2093984014 cites W1986996257 @default.
• W2093984014 cites W1988189113 @default.
• W2093984014 cites W1998721922 @default.
• W2093984014 cites W1999730387 @default.
• W2093984014 cites W2003867734 @default.
• W2093984014 cites W2015929217 @default.
• W2093984014 cites W2017364006 @default.
• W2093984014 cites W2017723141 @default.
• W2093984014 cites W2046574512 @default.
• W2093984014 cites W2051951572 @default.
• W2093984014 cites W2055425848 @default.
• W2093984014 cites W2070068459 @default.
• W2093984014 cites W2072015379 @default.
• W2093984014 cites W2072420392 @default.
• W2093984014 cites W2086615573 @default.
• W2093984014 cites W2094046904 @default.
• W2093984014 cites W2116394679 @default.
• W2093984014 cites W2141078753 @default.
• W2093984014 cites W2172060077 @default.
• W2093984014 cites W22846984 @default.
• W2093984014 doi "https://doi.org/10.1016/s0014-2999(01)01452-2" @default.
• W2093984014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11728427" @default.
• W2093984014 hasPublicationYear "2001" @default.
• W2093984014 type Work @default.
• W2093984014 sameAs 2093984014 @default.
• W2093984014 citedByCount "12" @default.
• W2093984014 countsByYear W20939840142012 @default.
• W2093984014 countsByYear W20939840142014 @default.
• W2093984014 countsByYear W20939840142017 @default.
• W2093984014 countsByYear W20939840142018 @default.
• W2093984014 countsByYear W20939840142019 @default.
• W2093984014 countsByYear W20939840142020 @default.
• W2093984014 countsByYear W20939840142021 @default.
• W2093984014 countsByYear W20939840142023 @default.
• W2093984014 crossrefType "journal-article" @default.
• W2093984014 hasAuthorship W2093984014A5008233161 @default.
• W2093984014 hasAuthorship W2093984014A5011949046 @default.
• W2093984014 hasAuthorship W2093984014A5023843044 @default.
• W2093984014 hasAuthorship W2093984014A5046320025 @default.
• W2093984014 hasAuthorship W2093984014A5087701130 @default.
• W2093984014 hasConcept C118552586 @default.
• W2093984014 hasConcept C126322002 @default.
• W2093984014 hasConcept C160268369 @default.
• W2093984014 hasConcept C170493617 @default.
• W2093984014 hasConcept C185592680 @default.
• W2093984014 hasConcept C189184402 @default.
• W2093984014 hasConcept C2775858608 @default.
• W2093984014 hasConcept C2776525901 @default.
• W2093984014 hasConcept C2776885963 @default.
• W2093984014 hasConcept C2777836312 @default.
• W2093984014 hasConcept C2778122271 @default.
• W2093984014 hasConcept C2778151854 @default.
• W2093984014 hasConcept C2778186239 @default.
• W2093984014 hasConcept C2778679995 @default.
• W2093984014 hasConcept C55493867 @default.
• W2093984014 hasConcept C61174792 @default.
• W2093984014 hasConcept C67018056 @default.
• W2093984014 hasConcept C71924100 @default.
• W2093984014 hasConcept C84393581 @default.
• W2093984014 hasConcept C98274493 @default.
• W2093984014 hasConceptScore W2093984014C118552586 @default.
• W2093984014 hasConceptScore W2093984014C126322002 @default.
• W2093984014 hasConceptScore W2093984014C160268369 @default.
• W2093984014 hasConceptScore W2093984014C170493617 @default.
• W2093984014 hasConceptScore W2093984014C185592680 @default.
• W2093984014 hasConceptScore W2093984014C189184402 @default.
• W2093984014 hasConceptScore W2093984014C2775858608 @default.
• W2093984014 hasConceptScore W2093984014C2776525901 @default.
• W2093984014 hasConceptScore W2093984014C2776885963 @default.
• W2093984014 hasConceptScore W2093984014C2777836312 @default.
• W2093984014 hasConceptScore W2093984014C2778122271 @default.
• W2093984014 hasConceptScore W2093984014C2778151854 @default.
• W2093984014 hasConceptScore W2093984014C2778186239 @default.
• W2093984014 hasConceptScore W2093984014C2778679995 @default.
• W2093984014 hasConceptScore W2093984014C55493867 @default.
• W2093984014 hasConceptScore W2093984014C61174792 @default.
• W2093984014 hasConceptScore W2093984014C67018056 @default.
• W2093984014 hasConceptScore W2093984014C71924100 @default.
• W2093984014 hasConceptScore W2093984014C84393581 @default.
• W2093984014 hasConceptScore W2093984014C98274493 @default.
• W2093984014 hasIssue "2" @default.
• W2093984014 hasLocation W20939840141 @default.
• W2093984014 hasLocation W20939840142 @default.

• next