FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093990216> ?p ?o ?g. }

• W2093990216 endingPage "619" @default.
• W2093990216 startingPage "599" @default.
• W2093990216 abstract "We have developed a system rSNP_Guide, , predicting the transcription factor (TF) binding sites on DNA, which mutation-caused alterations may explain disease penetration. rSNP_Guide uses the detected alterations in the mutant DNA binding to unknown TF caused by diseases and, upon the DNA sequences, calculates the alterations in known TF sites so that to select only the known ones with calculated alterations in the best consistence with those detected. Our system has been control tested on the SNP's with known site-disease relationships. For practical aims, two TF sites associated with diseases were predicted and confirmed by the immune assay with anti-TF antibodies. In the case of tumor susceptibility, the GATA site in the second intron of mouse K-ras gene was truly predicted, whereas mutation damage of this site causes tumor resistance. In the case of alcohol dependencies and others behavioral diseases, the mutation-caused spurious YY1 site in the sixth intron of human tryptophan 2,3-dioxygenase (TDO2) gene was successfully predicted. Finally, sixteen non-documented TF sites localizable at both orthologous and paralogous genes were first characterized by three rates present, weakened or absent, with significance estimated by rSNP_Guide relatively to six TF sites with known mutation-caused alterations in DNA/TF-binding." @default.
• W2093990216 created "2016-06-24" @default.
• W2093990216 creator A5025425343 @default.
• W2093990216 creator A5045830123 @default.
• W2093990216 creator A5058702341 @default.
• W2093990216 creator A5062514262 @default.
• W2093990216 creator A5070141127 @default.
• W2093990216 date "2005-08-01" @default.
• W2093990216 modified "2023-10-16" @default.
• W2093990216 title "MINING GENOME VARIATION TO ASSOCIATE GENETIC DISEASE WITH MUTATION ALTERATIONS AND ORTHO/PARALOGOUS POLIMORPHYSMS IN TRANSCRIPTION FACTOR BINDING SITE" @default.
• W2093990216 cites W1480160846 @default.
• W2093990216 cites W1491014964 @default.
• W2093990216 cites W1498410508 @default.
• W2093990216 cites W1539262549 @default.
• W2093990216 cites W1541541861 @default.
• W2093990216 cites W1543923901 @default.
• W2093990216 cites W1585348883 @default.
• W2093990216 cites W1967266877 @default.
• W2093990216 cites W1971316484 @default.
• W2093990216 cites W1973046634 @default.
• W2093990216 cites W1974839483 @default.
• W2093990216 cites W1975061104 @default.
• W2093990216 cites W1975283401 @default.
• W2093990216 cites W1989213989 @default.
• W2093990216 cites W1994127362 @default.
• W2093990216 cites W1999966058 @default.
• W2093990216 cites W2008900336 @default.
• W2093990216 cites W2018770945 @default.
• W2093990216 cites W2018924988 @default.
• W2093990216 cites W2021216485 @default.
• W2093990216 cites W2029474447 @default.
• W2093990216 cites W2031121939 @default.
• W2093990216 cites W2031967567 @default.
• W2093990216 cites W2032373442 @default.
• W2093990216 cites W2034619633 @default.
• W2093990216 cites W2035862933 @default.
• W2093990216 cites W2038440122 @default.
• W2093990216 cites W2044559869 @default.
• W2093990216 cites W2045586683 @default.
• W2093990216 cites W2053022925 @default.
• W2093990216 cites W2054016888 @default.
• W2093990216 cites W2056572328 @default.
• W2093990216 cites W2056865172 @default.
• W2093990216 cites W2058880489 @default.
• W2093990216 cites W2061008984 @default.
• W2093990216 cites W2064879068 @default.
• W2093990216 cites W2065087403 @default.
• W2093990216 cites W2066320604 @default.
• W2093990216 cites W2073115576 @default.
• W2093990216 cites W2076914276 @default.
• W2093990216 cites W2084681487 @default.
• W2093990216 cites W2099758791 @default.
• W2093990216 cites W2105383507 @default.
• W2093990216 cites W2112441656 @default.
• W2093990216 cites W2122534869 @default.
• W2093990216 cites W2122732537 @default.
• W2093990216 cites W2123243961 @default.
• W2093990216 cites W2129750721 @default.
• W2093990216 cites W2132781864 @default.
• W2093990216 cites W2136614521 @default.
• W2093990216 cites W2137570167 @default.
• W2093990216 cites W2141913814 @default.
• W2093990216 cites W2141936300 @default.
• W2093990216 cites W2144731690 @default.
• W2093990216 cites W2154514071 @default.
• W2093990216 cites W2160605780 @default.
• W2093990216 cites W2163390689 @default.
• W2093990216 cites W2168976934 @default.
• W2093990216 cites W2169351355 @default.
• W2093990216 cites W2476740399 @default.
• W2093990216 cites W2511444485 @default.
• W2093990216 cites W4211007335 @default.
• W2093990216 cites W96239223 @default.
• W2093990216 doi "https://doi.org/10.1142/s0218213005002284" @default.
• W2093990216 hasPublicationYear "2005" @default.
• W2093990216 type Work @default.
• W2093990216 sameAs 2093990216 @default.
• W2093990216 citedByCount "1" @default.
• W2093990216 countsByYear W20939902162016 @default.
• W2093990216 crossrefType "journal-article" @default.
• W2093990216 hasAuthorship W2093990216A5025425343 @default.
• W2093990216 hasAuthorship W2093990216A5045830123 @default.
• W2093990216 hasAuthorship W2093990216A5058702341 @default.
• W2093990216 hasAuthorship W2093990216A5062514262 @default.
• W2093990216 hasAuthorship W2093990216A5070141127 @default.
• W2093990216 hasConcept C101762097 @default.
• W2093990216 hasConcept C104317684 @default.
• W2093990216 hasConcept C107824862 @default.
• W2093990216 hasConcept C141231307 @default.
• W2093990216 hasConcept C143065580 @default.
• W2093990216 hasConcept C150194340 @default.
• W2093990216 hasConcept C197077220 @default.
• W2093990216 hasConcept C3662595 @default.
• W2093990216 hasConcept C501734568 @default.
• W2093990216 hasConcept C54355233 @default.
• W2093990216 hasConcept C552990157 @default.
• W2093990216 hasConcept C86339819 @default.
• W2093990216 hasConcept C86803240 @default.

• next