Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093990531> ?p ?o ?g. }
- W2093990531 endingPage "6933" @default.
- W2093990531 startingPage "6933" @default.
- W2093990531 abstract "Human breath is composed of many volatile metabolites that can potentially provide information about a person's health status. A sensitive assay to identify these volatile organic compounds as biomarkers is ideal and important for early detection of many diseases. However, the diagnosis through online breath analysis based on mass spectrometry is difficult due to the low concentration of pertinent compounds in breath. The DART (direct analysis in real time) ion source is a novel atmospheric pressure ionization technique, which can efficiently ionize gaseous, liquid and solid samples with high throughput. A major problem in analysis of gaseous samples is its poor detection sensitivity due to open-air sampling. Recently, a confined DART ion source (cDART) was developed, where the plasma generated by the atmospheric pressure glow discharge ionizes gas-phase molecules in a Tee-shaped flow tube instead of open air. It leads to a significant increase of the ionization efficiency of gaseous samples. In this study, the cDART source was modified and applied in online analysis of exhaled breath. The limit of detection of the improved cDART source was determined to be at the level of low ppb. The cDART source was used in the real-time monitoring of an oral anesthetic drug. The concentration variations of two active ingredients in exhaled breath, menthol and benzocaine, and their metabolites with time were obtained. The results show that the cDART ion source is a powerful analytical tool to provide high sensitivity and high throughput analysis for volatile organic compounds in human breath, and can find potential applications in clinical diagnosis and therapy." @default.
- W2093990531 created "2016-06-24" @default.
- W2093990531 creator A5044367029 @default.
- W2093990531 date "2013-01-01" @default.
- W2093990531 modified "2023-10-18" @default.
- W2093990531 title "Applications of a confined DART (direct analysis in real time) ion source for online in vivo analysis of human breath" @default.
- W2093990531 cites W1597705966 @default.
- W2093990531 cites W1966505632 @default.
- W2093990531 cites W1970011105 @default.
- W2093990531 cites W1971128511 @default.
- W2093990531 cites W1978578808 @default.
- W2093990531 cites W1980441757 @default.
- W2093990531 cites W1987001230 @default.
- W2093990531 cites W1988320008 @default.
- W2093990531 cites W1993179292 @default.
- W2093990531 cites W1994794188 @default.
- W2093990531 cites W1998960474 @default.
- W2093990531 cites W2005339690 @default.
- W2093990531 cites W2008260638 @default.
- W2093990531 cites W2009925494 @default.
- W2093990531 cites W2011472416 @default.
- W2093990531 cites W2011857126 @default.
- W2093990531 cites W2013893660 @default.
- W2093990531 cites W2015842895 @default.
- W2093990531 cites W2017224356 @default.
- W2093990531 cites W2026713007 @default.
- W2093990531 cites W2030255922 @default.
- W2093990531 cites W2034202559 @default.
- W2093990531 cites W2040599663 @default.
- W2093990531 cites W2048458691 @default.
- W2093990531 cites W2048541209 @default.
- W2093990531 cites W2051211320 @default.
- W2093990531 cites W2053459616 @default.
- W2093990531 cites W2053591916 @default.
- W2093990531 cites W2057847283 @default.
- W2093990531 cites W2061597971 @default.
- W2093990531 cites W2061643560 @default.
- W2093990531 cites W2063281883 @default.
- W2093990531 cites W2064124980 @default.
- W2093990531 cites W2067936850 @default.
- W2093990531 cites W2068541285 @default.
- W2093990531 cites W2073009608 @default.
- W2093990531 cites W2073304317 @default.
- W2093990531 cites W2073415606 @default.
- W2093990531 cites W2074694638 @default.
- W2093990531 cites W2078357450 @default.
- W2093990531 cites W2078389997 @default.
- W2093990531 cites W2083113508 @default.
- W2093990531 cites W2092538532 @default.
- W2093990531 cites W2097533880 @default.
- W2093990531 cites W2098463262 @default.
- W2093990531 cites W2100621873 @default.
- W2093990531 cites W2112729766 @default.
- W2093990531 cites W2127469323 @default.
- W2093990531 cites W2138741439 @default.
- W2093990531 cites W2149443601 @default.
- W2093990531 cites W2158319183 @default.
- W2093990531 cites W2171252662 @default.
- W2093990531 cites W2323963114 @default.
- W2093990531 cites W3100339243 @default.
- W2093990531 doi "https://doi.org/10.1039/c3ay41406j" @default.
- W2093990531 hasPublicationYear "2013" @default.
- W2093990531 type Work @default.
- W2093990531 sameAs 2093990531 @default.
- W2093990531 citedByCount "15" @default.
- W2093990531 countsByYear W20939905312015 @default.
- W2093990531 countsByYear W20939905312016 @default.
- W2093990531 countsByYear W20939905312017 @default.
- W2093990531 countsByYear W20939905312021 @default.
- W2093990531 countsByYear W20939905312022 @default.
- W2093990531 countsByYear W20939905312023 @default.
- W2093990531 crossrefType "journal-article" @default.
- W2093990531 hasAuthorship W2093990531A5044367029 @default.
- W2093990531 hasConcept C113196181 @default.
- W2093990531 hasConcept C118663420 @default.
- W2093990531 hasConcept C119128265 @default.
- W2093990531 hasConcept C138850012 @default.
- W2093990531 hasConcept C145148216 @default.
- W2093990531 hasConcept C148065180 @default.
- W2093990531 hasConcept C15213710 @default.
- W2093990531 hasConcept C162356407 @default.
- W2093990531 hasConcept C16291436 @default.
- W2093990531 hasConcept C178790620 @default.
- W2093990531 hasConcept C185592680 @default.
- W2093990531 hasConcept C188224857 @default.
- W2093990531 hasConcept C198291218 @default.
- W2093990531 hasConcept C199360897 @default.
- W2093990531 hasConcept C205759337 @default.
- W2093990531 hasConcept C2779417484 @default.
- W2093990531 hasConcept C41008148 @default.
- W2093990531 hasConcept C43617362 @default.
- W2093990531 hasConcept C51884965 @default.
- W2093990531 hasConcept C93353639 @default.
- W2093990531 hasConceptScore W2093990531C113196181 @default.
- W2093990531 hasConceptScore W2093990531C118663420 @default.
- W2093990531 hasConceptScore W2093990531C119128265 @default.
- W2093990531 hasConceptScore W2093990531C138850012 @default.
- W2093990531 hasConceptScore W2093990531C145148216 @default.