FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094002894> ?p ?o ?g. }

• W2094002894 endingPage "162" @default.
• W2094002894 startingPage "159" @default.
• W2094002894 abstract "BACKGROUND: The p21WAF1/CIP1 gene mediates growth arrest by inhibiting G1 cyclin dependent kinases and has been considered as a downstream effector of the tumour suppressor gene p53. AIM: To analyse the role of p21WAF1/CIP1 in gestational trophoblastic disease. METHODS: The immunohistochemical expression of p21WAF1/CIP1 gene was measured in 33 placentas, 28 partial hydatidiform moles, 54 complete hydatidiform moles, and 13 choriocarcinomas in paraffin wax embedded tissue. The results were correlated with p53 (DO7) and Ki67 (MIB1) immunoreactivity as well as clinical progress. RESULTS: p21WAF1/CIP1 immunoreactivity was found predominantly in the nuclei of the syncytiotrophoblasts. p21WAF1/CIP1 protein expression correlated with gestational age in normal placentas (p = 0.0001) but not in hydatidiform moles (p = 0.89). Complete hydatidiform moles and choriocarcinomas had a significantly higher p21WAF1/CIP1 expression compared with normal placentas and partial hydatidiform moles (p < 0.001); there was no difference between placentas and partial hydatidiform moles. No correlation between p21WAF1/CIP1 expression and either the proliferation (Ki67) index (p = 0.34) or p53 protein accumulation (p = 0.68) was demonstrated. There was no significant difference (p > 0.05) in p21WAF1/CIP1 expression between the 17 patients who developed persistent gestational trophoblastic disease and those who did not. CONCLUSIONS: This study suggests that p21WAF1/CIP1 expression in trophoblastic disease may be induced by a p53 independent pathway. The proliferative activity of gestational trophoblastic diseases might not be determined solely by the control of the cell cycle operated by p21WAF1/CIP1. p21WAF1/CIP1 expression is not an accurate prognostic indicator of gestational trophoblastic disease." @default.
• W2094002894 created "2016-06-24" @default.
• W2094002894 creator A5032937137 @default.
• W2094002894 creator A5040172079 @default.
• W2094002894 creator A5041325189 @default.
• W2094002894 creator A5058816598 @default.
• W2094002894 creator A5067608108 @default.
• W2094002894 date "1998-02-01" @default.
• W2094002894 modified "2023-09-27" @default.
• W2094002894 title "p21WAF1/CIP1 expression in gestational trophoblastic disease: correlation with clinicopathological parameters, and Ki67 and p53 gene expression" @default.
• W2094002894 cites W129012576 @default.
• W2094002894 cites W1527393478 @default.
• W2094002894 cites W1859231335 @default.
• W2094002894 cites W1908689712 @default.
• W2094002894 cites W1963692923 @default.
• W2094002894 cites W1979618464 @default.
• W2094002894 cites W1988661251 @default.
• W2094002894 cites W2000492992 @default.
• W2094002894 cites W2001293469 @default.
• W2094002894 cites W2003282728 @default.
• W2094002894 cites W2015519364 @default.
• W2094002894 cites W2017091696 @default.
• W2094002894 cites W2025213003 @default.
• W2094002894 cites W2032360738 @default.
• W2094002894 cites W203485332 @default.
• W2094002894 cites W2043892499 @default.
• W2094002894 cites W2051821346 @default.
• W2094002894 cites W2052651806 @default.
• W2094002894 cites W2057517373 @default.
• W2094002894 cites W2060916057 @default.
• W2094002894 cites W2068695274 @default.
• W2094002894 cites W2070061120 @default.
• W2094002894 cites W2083963563 @default.
• W2094002894 cites W2089218510 @default.
• W2094002894 cites W2135535670 @default.
• W2094002894 cites W2234533141 @default.
• W2094002894 cites W2275697044 @default.
• W2094002894 cites W2323425273 @default.
• W2094002894 cites W2412406914 @default.
• W2094002894 cites W2441879475 @default.
• W2094002894 cites W2470178980 @default.
• W2094002894 cites W79754562 @default.
• W2094002894 doi "https://doi.org/10.1136/jcp.51.2.159" @default.
• W2094002894 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/500513" @default.
• W2094002894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9602692" @default.
• W2094002894 hasPublicationYear "1998" @default.
• W2094002894 type Work @default.
• W2094002894 sameAs 2094002894 @default.
• W2094002894 citedByCount "36" @default.
• W2094002894 countsByYear W20940028942012 @default.
• W2094002894 countsByYear W20940028942013 @default.
• W2094002894 countsByYear W20940028942014 @default.
• W2094002894 countsByYear W20940028942018 @default.
• W2094002894 countsByYear W20940028942019 @default.
• W2094002894 crossrefType "journal-article" @default.
• W2094002894 hasAuthorship W2094002894A5032937137 @default.
• W2094002894 hasAuthorship W2094002894A5040172079 @default.
• W2094002894 hasAuthorship W2094002894A5041325189 @default.
• W2094002894 hasAuthorship W2094002894A5058816598 @default.
• W2094002894 hasAuthorship W2094002894A5067608108 @default.
• W2094002894 hasBestOaLocation W20940028941 @default.
• W2094002894 hasConcept C126322002 @default.
• W2094002894 hasConcept C134018914 @default.
• W2094002894 hasConcept C16685009 @default.
• W2094002894 hasConcept C172680121 @default.
• W2094002894 hasConcept C203014093 @default.
• W2094002894 hasConcept C204232928 @default.
• W2094002894 hasConcept C2776085573 @default.
• W2094002894 hasConcept C2776953305 @default.
• W2094002894 hasConcept C2778383414 @default.
• W2094002894 hasConcept C2779234561 @default.
• W2094002894 hasConcept C2908795334 @default.
• W2094002894 hasConcept C2908941940 @default.
• W2094002894 hasConcept C46973012 @default.
• W2094002894 hasConcept C502942594 @default.
• W2094002894 hasConcept C54355233 @default.
• W2094002894 hasConcept C71924100 @default.
• W2094002894 hasConcept C86803240 @default.
• W2094002894 hasConceptScore W2094002894C126322002 @default.
• W2094002894 hasConceptScore W2094002894C134018914 @default.
• W2094002894 hasConceptScore W2094002894C16685009 @default.
• W2094002894 hasConceptScore W2094002894C172680121 @default.
• W2094002894 hasConceptScore W2094002894C203014093 @default.
• W2094002894 hasConceptScore W2094002894C204232928 @default.
• W2094002894 hasConceptScore W2094002894C2776085573 @default.
• W2094002894 hasConceptScore W2094002894C2776953305 @default.
• W2094002894 hasConceptScore W2094002894C2778383414 @default.
• W2094002894 hasConceptScore W2094002894C2779234561 @default.
• W2094002894 hasConceptScore W2094002894C2908795334 @default.
• W2094002894 hasConceptScore W2094002894C2908941940 @default.
• W2094002894 hasConceptScore W2094002894C46973012 @default.
• W2094002894 hasConceptScore W2094002894C502942594 @default.
• W2094002894 hasConceptScore W2094002894C54355233 @default.
• W2094002894 hasConceptScore W2094002894C71924100 @default.
• W2094002894 hasConceptScore W2094002894C86803240 @default.
• W2094002894 hasIssue "2" @default.
• W2094002894 hasLocation W20940028941 @default.
• W2094002894 hasLocation W20940028942 @default.

• next