FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094005653> ?p ?o ?g. }

• W2094005653 endingPage "e140" @default.
• W2094005653 startingPage "e140" @default.
• W2094005653 abstract "Natively unstructured or disordered protein regions may increase the functional complexity of an organism; they are particularly abundant in eukaryotes and often evade structure determination. Many computational methods predict unstructured regions by training on outliers in otherwise well-ordered structures. Here, we introduce an approach that uses a neural network in a very different and novel way. We hypothesize that very long contiguous segments with nonregular secondary structure (NORS regions) differ significantly from regular, well-structured loops, and that a method detecting such features could predict natively unstructured regions. Training our new method, NORSnet, on predicted information rather than on experimental data yielded three major advantages: it removed the overlap between testing and training, it systematically covered entire proteomes, and it explicitly focused on one particular aspect of unstructured regions with a simple structural interpretation, namely that they are loops. Our hypothesis was correct: well-structured and unstructured loops differ so substantially that NORSnet succeeded in their distinction. Benchmarks on previously used and new experimental data of unstructured regions revealed that NORSnet performed very well. Although it was not the best single prediction method, NORSnet was sufficiently accurate to flag unstructured regions in proteins that were previously not annotated. In one application, NORSnet revealed previously undetected unstructured regions in putative targets for structural genomics and may thereby contribute to increasing structural coverage of large eukaryotic families. NORSnet found unstructured regions more often in domain boundaries than expected at random. In another application, we estimated that 50%-70% of all worm proteins observed to have more than seven protein-protein interaction partners have unstructured regions. The comparative analysis between NORSnet and DISOPRED2 suggested that long unstructured loops are a major part of unstructured regions in molecular networks." @default.
• W2094005653 created "2016-06-24" @default.
• W2094005653 creator A5048927341 @default.
• W2094005653 creator A5053624605 @default.
• W2094005653 creator A5064905883 @default.
• W2094005653 date "2007-07-20" @default.
• W2094005653 modified "2023-10-01" @default.
• W2094005653 title "Natively Unstructured Loops Differ from Other Loops" @default.
• W2094005653 cites W121768123 @default.
• W2094005653 cites W1499450468 @default.
• W2094005653 cites W1600814222 @default.
• W2094005653 cites W1602917883 @default.
• W2094005653 cites W1763894483 @default.
• W2094005653 cites W1792685479 @default.
• W2094005653 cites W1845459216 @default.
• W2094005653 cites W1847611580 @default.
• W2094005653 cites W1967974247 @default.
• W2094005653 cites W1975121208 @default.
• W2094005653 cites W1980015132 @default.
• W2094005653 cites W1983575462 @default.
• W2094005653 cites W1985818354 @default.
• W2094005653 cites W1988624456 @default.
• W2094005653 cites W1991879937 @default.
• W2094005653 cites W1995663955 @default.
• W2094005653 cites W2000093524 @default.
• W2094005653 cites W2006192061 @default.
• W2094005653 cites W2007016963 @default.
• W2094005653 cites W2007794469 @default.
• W2094005653 cites W2008708467 @default.
• W2094005653 cites W2011983814 @default.
• W2094005653 cites W2014776147 @default.
• W2094005653 cites W2020481171 @default.
• W2094005653 cites W2021093679 @default.
• W2094005653 cites W2030776726 @default.
• W2094005653 cites W2035487389 @default.
• W2094005653 cites W2050625197 @default.
• W2094005653 cites W2052606462 @default.
• W2094005653 cites W2055193239 @default.
• W2094005653 cites W2057289558 @default.
• W2094005653 cites W2064280962 @default.
• W2094005653 cites W2072649575 @default.
• W2094005653 cites W2075086532 @default.
• W2094005653 cites W2085029305 @default.
• W2094005653 cites W2092153867 @default.
• W2094005653 cites W2095259434 @default.
• W2094005653 cites W2096275987 @default.
• W2094005653 cites W2097209195 @default.
• W2094005653 cites W2099254366 @default.
• W2094005653 cites W2101220662 @default.
• W2094005653 cites W2101600610 @default.
• W2094005653 cites W2102025585 @default.
• W2094005653 cites W2102701612 @default.
• W2094005653 cites W2106853369 @default.
• W2094005653 cites W2110110505 @default.
• W2094005653 cites W2113019448 @default.
• W2094005653 cites W2114604135 @default.
• W2094005653 cites W2114823344 @default.
• W2094005653 cites W2115190629 @default.
• W2094005653 cites W2118432471 @default.
• W2094005653 cites W2119986079 @default.
• W2094005653 cites W2120881407 @default.
• W2094005653 cites W2124707779 @default.
• W2094005653 cites W2125725297 @default.
• W2094005653 cites W2128021885 @default.
• W2094005653 cites W2129421547 @default.
• W2094005653 cites W2131965976 @default.
• W2094005653 cites W2134327751 @default.
• W2094005653 cites W2135531426 @default.
• W2094005653 cites W2137259082 @default.
• W2094005653 cites W2137736270 @default.
• W2094005653 cites W2140481505 @default.
• W2094005653 cites W2141803423 @default.
• W2094005653 cites W2142529984 @default.
• W2094005653 cites W2149472608 @default.
• W2094005653 cites W2149822709 @default.
• W2094005653 cites W2152265734 @default.
• W2094005653 cites W2152282874 @default.
• W2094005653 cites W2153414768 @default.
• W2094005653 cites W2155144535 @default.
• W2094005653 cites W2155723007 @default.
• W2094005653 cites W2156407548 @default.
• W2094005653 cites W2156469184 @default.
• W2094005653 cites W2156678798 @default.
• W2094005653 cites W2158714788 @default.
• W2094005653 cites W2161199282 @default.
• W2094005653 cites W2162720882 @default.
• W2094005653 cites W2167785155 @default.
• W2094005653 cites W2168970921 @default.
• W2094005653 cites W2169085154 @default.
• W2094005653 cites W2486827194 @default.
• W2094005653 cites W2918011059 @default.
• W2094005653 doi "https://doi.org/10.1371/journal.pcbi.0030140" @default.
• W2094005653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1924875" @default.
• W2094005653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17658943" @default.
• W2094005653 hasPublicationYear "2007" @default.
• W2094005653 type Work @default.
• W2094005653 sameAs 2094005653 @default.
• W2094005653 citedByCount "89" @default.

• next