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- W2094006170 endingPage "224" @default.
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- W2094006170 abstract "Introduction: Lipid-based formulations have emerged as potential dosage forms to harvest effectively the therapeutic benefits of existing lipophilic molecules and new chemical entities. Compared with existing excipients, lipids by virtue of their unique physicochemical properties and resemblance to in vivo components demonstrate the extra advantage of improving the bioavailability of lipophilic and highly metabolizable drugs. Moreover, if used as the major excipient, lipids can reduce the required dose and even the toxicity of drugs with poor aqueous solubility. Areas covered: This review deals with the importance of multiparticulate systems in drug delivery, the therapeutic and manufacturing advantages of lipids as excipients, and the technological advances made so far in utilizing lipids for multiparticulate dosage forms, with emphasis on their application and success on an industrial scale. Lipids are being widely formulated into different multiparticulate dosage forms using innovative modifications of conventional equipment with relative ease, using methods such as melt-granulation, adsorption on solid support, spray-cooling, melt-extrusion/spheronization, freeze-pelletization, pastillation, and so on. Expert opinion: There is still a need to design new simple dosage forms and to upgrade existing manufacturing technology, in order to open up new avenues in drug delivery, for preparing patent non-infringing formulations of existing drug products, and to help patients receive treatment at an affordable cost." @default.
- W2094006170 created "2016-06-24" @default.
- W2094006170 creator A5038738287 @default.
- W2094006170 creator A5047734157 @default.
- W2094006170 creator A5083273808 @default.
- W2094006170 creator A5086064220 @default.
- W2094006170 date "2011-01-06" @default.
- W2094006170 modified "2023-10-01" @default.
- W2094006170 title "Lipid-based oral multiparticulate formulations – advantages, technological advances and industrial applications" @default.
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