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- W2094009369 abstract "Piperidine is one of pharmacologically active biogenic amines. While two pathways for piperidine production have been reported, little is known about metabolism of the compound. In the present study, piperidine and its hydroxylated, conjugated and unknown metabolites were detected in rat urine by radiochromato-graphic analysis. Using GC-MS technique, it was confirmed that 3-hydroxypiperidinc and 4-hydroxypipcridine are major metabolites of piperidine of either exogenous or endogenous origin. The findings substantiate the existence of a mechanism which inactivates piperidine in the living body, since both metabolites lack the potent pharmacological activities as those induced by piperidine." @default.
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- W2094009369 date "1978-01-01" @default.
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- W2094009369 title "METABOLITES OF PIPERIDINE IN RAT URINE" @default.
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- W2094009369 doi "https://doi.org/10.1254/jjp.28.41" @default.
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