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- W2094016988 abstract "Gonadotropin-releasing hormone agonist (GnRHa) triggered in vitro fertilization (IVF) cycles have similar reproductive outcomes compared with human chorionic gonadotropin (hCG) triggered cycles. A benefit of using a GnRHa or leuprolide acetate trigger is the decreased risk of ovarian hyperstimulation syndrome (OHSS). A leuprolide trigger has a luteolytic effect, which may negatively affect implantation rates. A freeze all IVF cycle with a subsequent frozen-thawed embryo transfer (FET) may help compensate for the luteolytic effect. The purpose of the study was to determine if there was a benefit to freezing all embryos with a subsequent FET compared with a fresh embryo transfer in leuprolide triggered IVF cycles. A retrospective chart review at a private fertility clinic was conducted after receiving IRB approval. All patients who received a leuprolide trigger between January 2010, when vitrification became the standard cryopreservation technique, and August 2012 were examined. Of 349 charts, 218 patients were included in the study with 141 cases in the fresh embryo transfer group and 72 cases in the FET group. Patients in the fresh group received intensive luteal support starting the day of oocyte retrieval, which included oral and transdermal estradiol as well as progesterone in oil. Data collection included patient demographics and IVF cycle results. The implantation and clinical pregnancy rates were the primary endpoints analyzed. Age, BMI, gravidity, total gonadotropin dose, number of oocytes retrieved, and fertilization rates were similar between the two groups. There were no cases of OHSS in either group. The number of embryos transferred was higher in the fresh embryo transfer group (P=0.001). Both the implantation and clinical pregnancy rates were higher in the FET group compared with the fresh embryo transfer group (P=0.0004; P=0.002) (see Table 1). When leuprolide is used in IVF cycles to trigger oocyte maturation, the pregnancy outcomes are improved when all of the embryos are frozen and then transferred in a subsequent cycle." @default.
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- W2094016988 date "2013-03-01" @default.
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- W2094016988 title "The Comparison of Pregnancy Outcomes in Fresh and Frozen-Thawed Embryo Transfers in Gonadotropin-Releasing Hormone Agonist Triggered In Vitro Fertilization Cycles" @default.
- W2094016988 doi "https://doi.org/10.1016/j.fertnstert.2013.01.067" @default.
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