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- W2094018565 endingPage "13804" @default.
- W2094018565 startingPage "13804" @default.
- W2094018565 abstract "Gastric cancer (GC) is a major public health issue as the fourth most common cancer and the second leading cause of cancer-related death. Recent advances have improved our understanding of its molecular pathogenesis, as best exemplified by elucidating the fundamental role of several major signaling pathways and related molecular derangements. Central to these mechanisms are the genetic and epigenetic alterations in these signaling pathways, such as gene mutations, copy number variants, aberrant gene methylation and histone modification, nucleosome positioning, and microRNAs. Some of these genetic/epigenetic alterations represent effective diagnostic and prognostic biomarkers and therapeutic targets for GC. This information has now opened unprecedented opportunities for better understanding of the molecular mechanisms of gastric carcinogenesis and the development of novel therapeutic strategies for this cancer. The pathogenetic mechanisms of GC are the focus of this review." @default.
- W2094018565 created "2016-06-24" @default.
- W2094018565 creator A5027790351 @default.
- W2094018565 creator A5038414554 @default.
- W2094018565 creator A5079970026 @default.
- W2094018565 date "2014-01-01" @default.
- W2094018565 modified "2023-10-16" @default.
- W2094018565 title "Pathogenetic mechanisms in gastric cancer" @default.
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