FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094043896> ?p ?o ?g. }

• W2094043896 endingPage "20" @default.
• W2094043896 startingPage "12" @default.
• W2094043896 abstract "Extracellular acidosis is a common feature in pain-generating pathological conditions. Acid-sensing ion channels (ASICs), pH sensors, are distributed in peripheral sensory neurons and participate in nociception. Morphine exerts potent analgesic effects through the activation of opioid receptors for various pain conditions. A cross-talk between ASICs and opioid receptors in peripheral sensory neurons has not been shown so far. Here, we have found that morphine inhibits the activity of native ASICs in rat dorsal root ganglion (DRG) neurons. Morphine dose-dependently inhibited proton-gated currents mediated by ASICs in the presence of the TRPV1 inhibitor capsazepine. Morphine shifted the proton concentration-response curve downwards, with a decrease of 51.4±3.8% in the maximum current response but with no significant change in the pH0.5 value. Another μ-opioid receptor agonist DAMGO induced a similar decrease in ASIC currents compared with morphine. The morphine inhibition of ASIC currents was blocked by naloxone, a specific opioid receptor antagonist. Pretreatment of forskolin, an adenylyl cyclase activator, or the addition of cAMP reversed the inhibitory effect of morphine. Moreover, morphine altered acid-evoked excitability of rat DRG neurons and decreased the number of action potentials induced by acid stimuli. Finally, peripheral applied morphine relieved pain evoked by intraplantar of acetic acid in rats. Our results indicate that morphine can inhibit the activity of ASICs via μ-opioid receptor and cAMP dependent signal pathway. These observations demonstrate a cross-talk between ASICs and opioid receptors in peripheral sensory neurons, which was a novel analgesic mechanism of morphine." @default.
• W2094043896 created "2016-06-24" @default.
• W2094043896 creator A5005562380 @default.
• W2094043896 creator A5029999167 @default.
• W2094043896 creator A5032129000 @default.
• W2094043896 creator A5035158354 @default.
• W2094043896 creator A5076863688 @default.
• W2094043896 creator A5082525673 @default.
• W2094043896 creator A5085762574 @default.
• W2094043896 date "2014-03-01" @default.
• W2094043896 modified "2023-10-14" @default.
• W2094043896 title "Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neurons" @default.
• W2094043896 cites W1509538734 @default.
• W2094043896 cites W1517054728 @default.
• W2094043896 cites W1528778201 @default.
• W2094043896 cites W1546862061 @default.
• W2094043896 cites W1635224753 @default.
• W2094043896 cites W1963627122 @default.
• W2094043896 cites W1964816489 @default.
• W2094043896 cites W1965498307 @default.
• W2094043896 cites W1974801463 @default.
• W2094043896 cites W1975779810 @default.
• W2094043896 cites W1984457480 @default.
• W2094043896 cites W1991705866 @default.
• W2094043896 cites W1993209115 @default.
• W2094043896 cites W2003192198 @default.
• W2094043896 cites W2011275944 @default.
• W2094043896 cites W2016367251 @default.
• W2094043896 cites W2016582600 @default.
• W2094043896 cites W2019839505 @default.
• W2094043896 cites W2025537889 @default.
• W2094043896 cites W2028297619 @default.
• W2094043896 cites W2033457590 @default.
• W2094043896 cites W2047283239 @default.
• W2094043896 cites W2050529708 @default.
• W2094043896 cites W2075711087 @default.
• W2094043896 cites W2078879971 @default.
• W2094043896 cites W2085805107 @default.
• W2094043896 cites W2105080299 @default.
• W2094043896 cites W2116147934 @default.
• W2094043896 cites W2129935026 @default.
• W2094043896 cites W2131273766 @default.
• W2094043896 cites W2137678794 @default.
• W2094043896 cites W2140478861 @default.
• W2094043896 cites W2145360888 @default.
• W2094043896 cites W2148132100 @default.
• W2094043896 cites W2158057345 @default.
• W2094043896 cites W2159543883 @default.
• W2094043896 cites W2165249332 @default.
• W2094043896 cites W2167673522 @default.
• W2094043896 cites W4238017164 @default.
• W2094043896 doi "https://doi.org/10.1016/j.brainres.2014.01.042" @default.
• W2094043896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24491633" @default.
• W2094043896 hasPublicationYear "2014" @default.
• W2094043896 type Work @default.
• W2094043896 sameAs 2094043896 @default.
• W2094043896 citedByCount "33" @default.
• W2094043896 countsByYear W20940438962016 @default.
• W2094043896 countsByYear W20940438962017 @default.
• W2094043896 countsByYear W20940438962018 @default.
• W2094043896 countsByYear W20940438962019 @default.
• W2094043896 countsByYear W20940438962020 @default.
• W2094043896 countsByYear W20940438962021 @default.
• W2094043896 countsByYear W20940438962022 @default.
• W2094043896 countsByYear W20940438962023 @default.
• W2094043896 crossrefType "journal-article" @default.
• W2094043896 hasAuthorship W2094043896A5005562380 @default.
• W2094043896 hasAuthorship W2094043896A5029999167 @default.
• W2094043896 hasAuthorship W2094043896A5032129000 @default.
• W2094043896 hasAuthorship W2094043896A5035158354 @default.
• W2094043896 hasAuthorship W2094043896A5076863688 @default.
• W2094043896 hasAuthorship W2094043896A5082525673 @default.
• W2094043896 hasAuthorship W2094043896A5085762574 @default.
• W2094043896 hasConcept C143928317 @default.
• W2094043896 hasConcept C155164980 @default.
• W2094043896 hasConcept C160145004 @default.
• W2094043896 hasConcept C169760540 @default.
• W2094043896 hasConcept C170493617 @default.
• W2094043896 hasConcept C185592680 @default.
• W2094043896 hasConcept C2776281502 @default.
• W2094043896 hasConcept C2776401185 @default.
• W2094043896 hasConcept C2777389121 @default.
• W2094043896 hasConcept C2777953665 @default.
• W2094043896 hasConcept C2778750930 @default.
• W2094043896 hasConcept C2778938600 @default.
• W2094043896 hasConcept C2779178603 @default.
• W2094043896 hasConcept C2779886867 @default.
• W2094043896 hasConcept C2780071552 @default.
• W2094043896 hasConcept C2781063702 @default.
• W2094043896 hasConcept C50254741 @default.
• W2094043896 hasConcept C55493867 @default.
• W2094043896 hasConcept C71924100 @default.
• W2094043896 hasConcept C86803240 @default.
• W2094043896 hasConcept C94487597 @default.
• W2094043896 hasConcept C98274493 @default.
• W2094043896 hasConceptScore W2094043896C143928317 @default.
• W2094043896 hasConceptScore W2094043896C155164980 @default.
• W2094043896 hasConceptScore W2094043896C160145004 @default.

• next