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• W2094044559 abstract "Crosstalk between immunity and the thermogenic program has provided insight into metabolic energy regulation. Here, we generated thermogenic program-accelerating mice (T-QKO), in which Foxo1 is knockout and Foxo3 is hetero-knockout in CD4+ T cells. T-QKO exhibit lean phenotype under HFD due to increased energy expenditure. Cold exposure significantly increased expression of the thermogenic genes (Ppargc1a and Ucp1), Th2 cytokines (Il4 and Il13), and Th2 marker gene (Gata3) in subcutaneous adipose tissue (SC) of T-QKO. Furthermore, Ccr4 expression was significantly increased in Th2 cells of T-QKO, and cold exposure induced Ccl22 expression in SC, leading to increased accumulation of Th2 cell population in SC of T-QKO. These data reveal a mechanism by which cold exposure induces selective recruitment of Th2 cells into SC, leading to regulation of energy expenditure by generating beige adipocyte and suggest that inhibition of Foxo in T cells may support a strategy to prevent and treat obesity." @default.
• W2094044559 created "2016-06-24" @default.
• W2094044559 creator A5090217037 @default.
• W2094044559 date "2004-08-01" @default.
• W2094044559 modified "2023-10-11" @default.
• W2094044559 title "Animal models of nonalcoholic fatty liver disease and steatohepatitis" @default.
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• W2094044559 cites W165688990 @default.
• W2094044559 cites W1671834350 @default.
• W2094044559 cites W1790943011 @default.
• W2094044559 cites W1900337449 @default.
• W2094044559 cites W1940103863 @default.
• W2094044559 cites W1943105996 @default.
• W2094044559 cites W1963533730 @default.
• W2094044559 cites W1964624702 @default.
• W2094044559 cites W1967502002 @default.
• W2094044559 cites W1970446214 @default.
• W2094044559 cites W1975962309 @default.
• W2094044559 cites W1986323764 @default.
• W2094044559 cites W1992209802 @default.
• W2094044559 cites W1992864925 @default.
• W2094044559 cites W1993170631 @default.
• W2094044559 cites W1996713062 @default.
• W2094044559 cites W2000017511 @default.
• W2094044559 cites W2002790732 @default.
• W2094044559 cites W2004861205 @default.
• W2094044559 cites W2008688211 @default.
• W2094044559 cites W2012508659 @default.
• W2094044559 cites W2016716965 @default.
• W2094044559 cites W2020505711 @default.
• W2094044559 cites W2022763702 @default.
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• W2094044559 cites W2090130376 @default.
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• W2094044559 doi "https://doi.org/10.1016/j.cld.2004.04.002" @default.
• W2094044559 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15331064" @default.
• W2094044559 hasPublicationYear "2004" @default.
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