FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094056478> ?p ?o ?g. }

• W2094056478 endingPage "10423" @default.
• W2094056478 startingPage "10413" @default.
• W2094056478 abstract "ABSTRACT Hypoxia-inducible factor 1 (HIF-1) is a ubiquitously expressed transcriptional regulator involved in induction of numerous genes associated with angiogenesis and tumor growth. Kaposi's sarcoma, associated with increased angiogenesis, is a highly vascularized, endothelial cell-derived tumor. Previously, we have shown that the latency-associated nuclear antigen (LANA) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) targets the HIF-1α suppressors von Hippel-Lindau protein and p53 for degradation via its suppressor of cytokine signaling-box motif, which recruits the EC 5 S ubiquitin complex. Here we further show that HIF-1α was aberrantly accumulated in KSHV latently infected primary effusion lymphoma (PEL) cells, as well as HEK293 cells infected with KSHV, and also show that a potential α-helical amino-terminal domain of LANA was important for HIF-1α nuclear accumulation in normoxic conditions. Moreover, we have now determined that this association was dependent on the residues 46 to 89 of LANA and the oxygen-dependent degradation domain of HIF-1α. Introduction of specific small interfering RNA against LANA into PEL cells also resulted in a diminished nuclear accumulation of HIF-1α. Therefore, these data show that LANA can function not only as an inhibitor of HIF-1α suppressor proteins but can also induce nuclear accumulation of HIF-1α during KSHV latent infection." @default.
• W2094056478 created "2016-06-24" @default.
• W2094056478 creator A5019927913 @default.
• W2094056478 creator A5032066345 @default.
• W2094056478 creator A5062541744 @default.
• W2094056478 creator A5071309906 @default.
• W2094056478 date "2007-10-01" @default.
• W2094056478 modified "2023-09-30" @default.
• W2094056478 title "A Potential α-Helix Motif in the Amino Terminus of LANA Encoded by Kaposi's Sarcoma-Associated Herpesvirus Is Critical for Nuclear Accumulation of HIF-1α in Normoxia" @default.
• W2094056478 cites W1491026704 @default.
• W2094056478 cites W1493048246 @default.
• W2094056478 cites W1509190906 @default.
• W2094056478 cites W1532938692 @default.
• W2094056478 cites W1604210388 @default.
• W2094056478 cites W1673837423 @default.
• W2094056478 cites W1749022239 @default.
• W2094056478 cites W1797937433 @default.
• W2094056478 cites W1974538337 @default.
• W2094056478 cites W1978720404 @default.
• W2094056478 cites W1987156249 @default.
• W2094056478 cites W1995254238 @default.
• W2094056478 cites W1995912453 @default.
• W2094056478 cites W2011810742 @default.
• W2094056478 cites W2021522625 @default.
• W2094056478 cites W2024976039 @default.
• W2094056478 cites W2026994755 @default.
• W2094056478 cites W2027587005 @default.
• W2094056478 cites W2030384820 @default.
• W2094056478 cites W2032438721 @default.
• W2094056478 cites W2036966242 @default.
• W2094056478 cites W2042645421 @default.
• W2094056478 cites W2054271458 @default.
• W2094056478 cites W2069698188 @default.
• W2094056478 cites W2070266075 @default.
• W2094056478 cites W2071580019 @default.
• W2094056478 cites W2074770401 @default.
• W2094056478 cites W2074824347 @default.
• W2094056478 cites W2085609942 @default.
• W2094056478 cites W2085724817 @default.
• W2094056478 cites W2093884797 @default.
• W2094056478 cites W2099791897 @default.
• W2094056478 cites W2099933670 @default.
• W2094056478 cites W2106882164 @default.
• W2094056478 cites W2112077864 @default.
• W2094056478 cites W2112337731 @default.
• W2094056478 cites W2124287509 @default.
• W2094056478 cites W2125724189 @default.
• W2094056478 cites W2130219349 @default.
• W2094056478 cites W2136990658 @default.
• W2094056478 cites W2143090686 @default.
• W2094056478 cites W2146707443 @default.
• W2094056478 cites W2148326208 @default.
• W2094056478 cites W2159163386 @default.
• W2094056478 cites W2167901553 @default.
• W2094056478 cites W2336241188 @default.
• W2094056478 cites W2410723119 @default.
• W2094056478 cites W2580449060 @default.
• W2094056478 cites W4285719527 @default.
• W2094056478 cites W4294718043 @default.
• W2094056478 cites W69516432 @default.
• W2094056478 cites W7317053 @default.
• W2094056478 doi "https://doi.org/10.1128/jvi.00611-07" @default.
• W2094056478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2045494" @default.
• W2094056478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17634230" @default.
• W2094056478 hasPublicationYear "2007" @default.
• W2094056478 type Work @default.
• W2094056478 sameAs 2094056478 @default.
• W2094056478 citedByCount "76" @default.
• W2094056478 countsByYear W20940564782012 @default.
• W2094056478 countsByYear W20940564782013 @default.
• W2094056478 countsByYear W20940564782014 @default.
• W2094056478 countsByYear W20940564782015 @default.
• W2094056478 countsByYear W20940564782016 @default.
• W2094056478 countsByYear W20940564782017 @default.
• W2094056478 countsByYear W20940564782018 @default.
• W2094056478 countsByYear W20940564782019 @default.
• W2094056478 countsByYear W20940564782020 @default.
• W2094056478 countsByYear W20940564782021 @default.
• W2094056478 countsByYear W20940564782022 @default.
• W2094056478 countsByYear W20940564782023 @default.
• W2094056478 crossrefType "journal-article" @default.
• W2094056478 hasAuthorship W2094056478A5019927913 @default.
• W2094056478 hasAuthorship W2094056478A5032066345 @default.
• W2094056478 hasAuthorship W2094056478A5062541744 @default.
• W2094056478 hasAuthorship W2094056478A5071309906 @default.
• W2094056478 hasBestOaLocation W20940564781 @default.
• W2094056478 hasConcept C104317684 @default.
• W2094056478 hasConcept C153911025 @default.
• W2094056478 hasConcept C159047783 @default.
• W2094056478 hasConcept C160450060 @default.
• W2094056478 hasConcept C190062978 @default.
• W2094056478 hasConcept C2522874641 @default.
• W2094056478 hasConcept C2776409557 @default.
• W2094056478 hasConcept C2779594685 @default.
• W2094056478 hasConcept C2780114586 @default.
• W2094056478 hasConcept C2780394083 @default.
• W2094056478 hasConcept C2780727368 @default.
• W2094056478 hasConcept C2780797929 @default.

• next