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- W2094057543 abstract "Middle T antigen (MT) is the principal oncogene of murine polyomavirus. Its study has led to the discovery of the roles of tyrosine kinase and phosphoinositide 3-kinase (PI3K) signaling in mammalian growth control and transformation. MT is necessary for viral transformation in tissue culture cells and tumorigenesis in animals. When expressed alone as a transgene, MT causes tumors in a wide variety of tissues. It has no known catalytic activity, but rather acts by assembling cellular signal transduction molecules. Protein phosphatase 2A, protein tyrosine kinases of the src family, PI3K, phospholipase Cγ1 as well as the Shc/Grb2 adaptors are all assembled on MT. Their activation sets off a series of signaling cascades. Analyses of virus mutants as well as transgenic animals have demonstrated that the effects of a given signal depend not only tissue type, but on the genetic background of the host animal. There remain many opportunities as we seek a full molecular understanding of MT and apply some of its lessons to human cancer." @default.
- W2094057543 created "2016-06-24" @default.
- W2094057543 creator A5029245218 @default.
- W2094057543 creator A5067826915 @default.
- W2094057543 date "2009-02-01" @default.
- W2094057543 modified "2023-09-26" @default.
- W2094057543 title "Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer" @default.
- W2094057543 cites W1485025953 @default.
- W2094057543 cites W1493181576 @default.
- W2094057543 cites W1499933591 @default.
- W2094057543 cites W1504765929 @default.
- W2094057543 cites W1505697879 @default.
- W2094057543 cites W1519008651 @default.
- W2094057543 cites W1530265515 @default.
- W2094057543 cites W1530828103 @default.
- W2094057543 cites W1533683254 @default.
- W2094057543 cites W1535935167 @default.
- W2094057543 cites W1538015091 @default.
- W2094057543 cites W1538123806 @default.
- W2094057543 cites W1538167629 @default.
- W2094057543 cites W1539837817 @default.
- W2094057543 cites W1542117945 @default.
- W2094057543 cites W1550737703 @default.
- W2094057543 cites W1551069705 @default.
- W2094057543 cites W1574131335 @default.
- W2094057543 cites W1581372463 @default.
- W2094057543 cites W1594926982 @default.
- W2094057543 cites W1595085053 @default.
- W2094057543 cites W1638981824 @default.
- W2094057543 cites W1687787740 @default.
- W2094057543 cites W1749869160 @default.
- W2094057543 cites W1779251134 @default.
- W2094057543 cites W1830631529 @default.
- W2094057543 cites W1837845068 @default.
- W2094057543 cites W1838131144 @default.
- W2094057543 cites W1849606007 @default.
- W2094057543 cites W1863688205 @default.
- W2094057543 cites W1888312006 @default.
- W2094057543 cites W1892174448 @default.
- W2094057543 cites W1920844816 @default.
- W2094057543 cites W1927276413 @default.
- W2094057543 cites W1937185223 @default.
- W2094057543 cites W1940244874 @default.
- W2094057543 cites W1946820589 @default.
- W2094057543 cites W1953036954 @default.
- W2094057543 cites W1956641674 @default.
- W2094057543 cites W1964694209 @default.
- W2094057543 cites W1968938192 @default.
- W2094057543 cites W1969219687 @default.
- W2094057543 cites W1971212979 @default.
- W2094057543 cites W1971333358 @default.
- W2094057543 cites W1972035895 @default.
- W2094057543 cites W1972086241 @default.
- W2094057543 cites W1972187212 @default.
- W2094057543 cites W1972236331 @default.
- W2094057543 cites W1974517994 @default.
- W2094057543 cites W1976858193 @default.
- W2094057543 cites W1977218754 @default.
- W2094057543 cites W1981076681 @default.
- W2094057543 cites W1985187767 @default.
- W2094057543 cites W1986128738 @default.
- W2094057543 cites W1986492134 @default.
- W2094057543 cites W1986679685 @default.
- W2094057543 cites W1986758681 @default.
- W2094057543 cites W1989009382 @default.
- W2094057543 cites W1990394302 @default.
- W2094057543 cites W199182958 @default.
- W2094057543 cites W2000217512 @default.
- W2094057543 cites W2001285899 @default.
- W2094057543 cites W2001600598 @default.
- W2094057543 cites W2002570553 @default.
- W2094057543 cites W2003282897 @default.
- W2094057543 cites W2005536723 @default.
- W2094057543 cites W2008008296 @default.
- W2094057543 cites W2011147958 @default.
- W2094057543 cites W2012120087 @default.
- W2094057543 cites W2013456957 @default.
- W2094057543 cites W2014900282 @default.
- W2094057543 cites W2017141883 @default.
- W2094057543 cites W2017466836 @default.
- W2094057543 cites W2017499074 @default.
- W2094057543 cites W2017958579 @default.
- W2094057543 cites W2020537787 @default.
- W2094057543 cites W2020961681 @default.
- W2094057543 cites W2021029116 @default.
- W2094057543 cites W2023777516 @default.
- W2094057543 cites W2024682565 @default.
- W2094057543 cites W2026466875 @default.
- W2094057543 cites W2027334739 @default.
- W2094057543 cites W2028740451 @default.
- W2094057543 cites W2029675011 @default.
- W2094057543 cites W2030577752 @default.
- W2094057543 cites W2031294112 @default.
- W2094057543 cites W2032201290 @default.
- W2094057543 cites W2033999408 @default.
- W2094057543 cites W2034056021 @default.
- W2094057543 cites W2035835036 @default.
- W2094057543 cites W2038239424 @default.