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- W2094066944 abstract "<h3>Objective</h3> To examine the changing trend of plasma Neutrophil gelatinase-associated lipocalin (NGAL) after contrast exposure and to elucidate whether NGAL was good early biomarker for diagnosis of contrast induced acute kidney injury (CIAKI). <h3>Method</h3> 231 patients undergoing percutaneous coronary intervention were enrolled. Blood samples were collected before and 2, 4, 8, 24, and 48 h after procedure. NGAL was measured with ELISA kit. CIAKI was defined as an increase in the serum creatinine values of ≥25% or ≥44.2 μmol/L. Receiver-operating characteristic (ROC) curves were generated and the area under the curve (AUC) calculated. <h3>Results</h3> At baseline, the plasma NGAL (69.4±29.8 ng/ml) was correlated positively with creatinine (90.9±20.4 μmol/L) (r<sup>2</sup>=0.341, p<0.001) The plasma NGAL increased at 2 h and reached peak at 8 h and decreased at 24 h after procedures. Among all the patients, 29 patients (12.6%) developed CIAKI. The sensitivity, specificity, and ROC curve for prediction of CIN were excellent for the 2 h plasma NGAL (75%, 89%, and 0.90, respectively). <h3>Conclusion</h3> NGAL seems to be a potential early biomarker for CIAKI." @default.
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- W2094066944 date "2010-10-01" @default.
- W2094066944 modified "2023-09-25" @default.
- W2094066944 title "e0513 Plasma NGAL Could early predict contrast-induced acute kidney injury after percutaneous coronary interventions" @default.
- W2094066944 doi "https://doi.org/10.1136/hrt.2010.208967.513" @default.
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