Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094072010> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2094072010 abstract "We report here that staurosporine can induce apoptosis or differentiation of granulosa tumor cells depending on its dosage. In presence of staurosporine concentrations > 50 nM, apoptosis was triggered in human granulosa cell tumor cells COV434. In the presence of concentrations < 50 nM, the shape of the otherwise globular granulosa cells differentiated into a flattened epithelioid-like appearance. The process was associated by the induction of prostaglandin synthase-2 (PGS-2) and C/EBPbeta expression and by an increase in progesterone production in the supernatant culture medium. The observed effects of staurosporine were synergized by forskolin. With phosphorylation-specific Western blotting and protein kinase assays, it was demonstrated that staurosporine suppresses the phosphorylation of p38 and activates JNK. These results suggest that p38MAPK and JNK signal transduction pathways were involved in the regulation of granulosa cell differentiation by staurosporine. These results may indicate the usefulness of staurosporine or its analogs for the development of a future medical treatment of granulosa tumors." @default.
- W2094072010 created "2016-06-24" @default.
- W2094072010 creator A5013150384 @default.
- W2094072010 creator A5015106592 @default.
- W2094072010 creator A5046492899 @default.
- W2094072010 creator A5065460455 @default.
- W2094072010 creator A5069849278 @default.
- W2094072010 date "2005-06-01" @default.
- W2094072010 modified "2023-09-25" @default.
- W2094072010 title "Apoptosis and differentiation induced by staurosporine in granulosa tumor cells is coupled with activation of JNK and suppression of p38 MAPK" @default.
- W2094072010 cites W1616213090 @default.
- W2094072010 cites W1965490734 @default.
- W2094072010 cites W1969435130 @default.
- W2094072010 cites W1974520908 @default.
- W2094072010 cites W2011327659 @default.
- W2094072010 cites W2020903076 @default.
- W2094072010 cites W2023879649 @default.
- W2094072010 cites W2028618614 @default.
- W2094072010 cites W2069998560 @default.
- W2094072010 cites W2071257072 @default.
- W2094072010 cites W2106123852 @default.
- W2094072010 cites W2138165502 @default.
- W2094072010 cites W2160353038 @default.
- W2094072010 cites W324549396 @default.
- W2094072010 doi "https://doi.org/10.3892/ijo.26.6.1575" @default.
- W2094072010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15870872" @default.
- W2094072010 hasPublicationYear "2005" @default.
- W2094072010 type Work @default.
- W2094072010 sameAs 2094072010 @default.
- W2094072010 citedByCount "10" @default.
- W2094072010 countsByYear W20940720102012 @default.
- W2094072010 countsByYear W20940720102013 @default.
- W2094072010 countsByYear W20940720102017 @default.
- W2094072010 countsByYear W20940720102023 @default.
- W2094072010 crossrefType "journal-article" @default.
- W2094072010 hasAuthorship W2094072010A5013150384 @default.
- W2094072010 hasAuthorship W2094072010A5015106592 @default.
- W2094072010 hasAuthorship W2094072010A5046492899 @default.
- W2094072010 hasAuthorship W2094072010A5065460455 @default.
- W2094072010 hasAuthorship W2094072010A5069849278 @default.
- W2094072010 hasConcept C11960822 @default.
- W2094072010 hasConcept C134018914 @default.
- W2094072010 hasConcept C184235292 @default.
- W2094072010 hasConcept C190283241 @default.
- W2094072010 hasConcept C24998067 @default.
- W2094072010 hasConcept C2779084600 @default.
- W2094072010 hasConcept C2779276759 @default.
- W2094072010 hasConcept C502942594 @default.
- W2094072010 hasConcept C51551487 @default.
- W2094072010 hasConcept C55493867 @default.
- W2094072010 hasConcept C57074206 @default.
- W2094072010 hasConcept C62478195 @default.
- W2094072010 hasConcept C86803240 @default.
- W2094072010 hasConcept C95444343 @default.
- W2094072010 hasConcept C97029542 @default.
- W2094072010 hasConceptScore W2094072010C11960822 @default.
- W2094072010 hasConceptScore W2094072010C134018914 @default.
- W2094072010 hasConceptScore W2094072010C184235292 @default.
- W2094072010 hasConceptScore W2094072010C190283241 @default.
- W2094072010 hasConceptScore W2094072010C24998067 @default.
- W2094072010 hasConceptScore W2094072010C2779084600 @default.
- W2094072010 hasConceptScore W2094072010C2779276759 @default.
- W2094072010 hasConceptScore W2094072010C502942594 @default.
- W2094072010 hasConceptScore W2094072010C51551487 @default.
- W2094072010 hasConceptScore W2094072010C55493867 @default.
- W2094072010 hasConceptScore W2094072010C57074206 @default.
- W2094072010 hasConceptScore W2094072010C62478195 @default.
- W2094072010 hasConceptScore W2094072010C86803240 @default.
- W2094072010 hasConceptScore W2094072010C95444343 @default.
- W2094072010 hasConceptScore W2094072010C97029542 @default.
- W2094072010 hasLocation W20940720101 @default.
- W2094072010 hasLocation W20940720102 @default.
- W2094072010 hasOpenAccess W2094072010 @default.
- W2094072010 hasPrimaryLocation W20940720101 @default.
- W2094072010 hasRelatedWork W196367670 @default.
- W2094072010 hasRelatedWork W1976734851 @default.
- W2094072010 hasRelatedWork W2004726042 @default.
- W2094072010 hasRelatedWork W2010932108 @default.
- W2094072010 hasRelatedWork W2029614856 @default.
- W2094072010 hasRelatedWork W205417214 @default.
- W2094072010 hasRelatedWork W2765877633 @default.
- W2094072010 hasRelatedWork W2978781268 @default.
- W2094072010 hasRelatedWork W3141260101 @default.
- W2094072010 hasRelatedWork W4254421120 @default.
- W2094072010 isParatext "false" @default.
- W2094072010 isRetracted "false" @default.
- W2094072010 magId "2094072010" @default.
- W2094072010 workType "article" @default.