Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094075461> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2094075461 abstract "Earlier experiments suggest that the evolutionary information (conservation of amino acids and coevolution between amino acids) encoded in protein sequences is necessary and sufficient to specify the fold of a protein family. However, there is no computational work to quantify the effect of such evolutionary information on the folding process. Here we simulate a repertoire of native and artificial WW domain sequences using a physics-based protein structure search method called ZAM (Zipping and Assembly method), which samples conformational space effectively towards native-like conformations through zipping and assembly search mechanism. We explore the sequence-structure relationship for WW domains and find that the coevolution information has a remarkable influence on local contacts of N-terminal β-turn of WW domains. This turn would not form correctly in the absence of such information. Moreover, through maximum likelihood approach, we identify five local contacts that play a critical role in folding. using the contact probability of those five local contacts at the early stage of folding, we built a classification model. This enables us to predict the foldability of a WW sequence with 81% accuracy. Based on this classification model, we re-design the unfoldable WW domain sequences and make them foldable by introducing a few mutations that lead to stabilization of these critical contacts." @default.
- W2094075461 created "2016-06-24" @default.
- W2094075461 creator A5027098692 @default.
- W2094075461 creator A5031821234 @default.
- W2094075461 creator A5072113448 @default.
- W2094075461 creator A5090364916 @default.
- W2094075461 date "2013-01-01" @default.
- W2094075461 modified "2023-09-26" @default.
- W2094075461 title "Deciphering the Protein Folding Code through Zipping Steps" @default.
- W2094075461 doi "https://doi.org/10.1016/j.bpj.2012.11.2220" @default.
- W2094075461 hasPublicationYear "2013" @default.
- W2094075461 type Work @default.
- W2094075461 sameAs 2094075461 @default.
- W2094075461 citedByCount "0" @default.
- W2094075461 crossrefType "journal-article" @default.
- W2094075461 hasAuthorship W2094075461A5027098692 @default.
- W2094075461 hasAuthorship W2094075461A5031821234 @default.
- W2094075461 hasAuthorship W2094075461A5072113448 @default.
- W2094075461 hasAuthorship W2094075461A5090364916 @default.
- W2094075461 hasBestOaLocation W20940754611 @default.
- W2094075461 hasConcept C104317684 @default.
- W2094075461 hasConcept C119599485 @default.
- W2094075461 hasConcept C121332964 @default.
- W2094075461 hasConcept C127413603 @default.
- W2094075461 hasConcept C134306372 @default.
- W2094075461 hasConcept C144292202 @default.
- W2094075461 hasConcept C177264268 @default.
- W2094075461 hasConcept C199360897 @default.
- W2094075461 hasConcept C204328495 @default.
- W2094075461 hasConcept C204491159 @default.
- W2094075461 hasConcept C24890656 @default.
- W2094075461 hasConcept C2776545253 @default.
- W2094075461 hasConcept C2776760102 @default.
- W2094075461 hasConcept C2778112365 @default.
- W2094075461 hasConcept C2778473898 @default.
- W2094075461 hasConcept C33009525 @default.
- W2094075461 hasConcept C33923547 @default.
- W2094075461 hasConcept C36503486 @default.
- W2094075461 hasConcept C41008148 @default.
- W2094075461 hasConcept C54355233 @default.
- W2094075461 hasConcept C55493867 @default.
- W2094075461 hasConcept C70721500 @default.
- W2094075461 hasConcept C78458016 @default.
- W2094075461 hasConcept C86803240 @default.
- W2094075461 hasConceptScore W2094075461C104317684 @default.
- W2094075461 hasConceptScore W2094075461C119599485 @default.
- W2094075461 hasConceptScore W2094075461C121332964 @default.
- W2094075461 hasConceptScore W2094075461C127413603 @default.
- W2094075461 hasConceptScore W2094075461C134306372 @default.
- W2094075461 hasConceptScore W2094075461C144292202 @default.
- W2094075461 hasConceptScore W2094075461C177264268 @default.
- W2094075461 hasConceptScore W2094075461C199360897 @default.
- W2094075461 hasConceptScore W2094075461C204328495 @default.
- W2094075461 hasConceptScore W2094075461C204491159 @default.
- W2094075461 hasConceptScore W2094075461C24890656 @default.
- W2094075461 hasConceptScore W2094075461C2776545253 @default.
- W2094075461 hasConceptScore W2094075461C2776760102 @default.
- W2094075461 hasConceptScore W2094075461C2778112365 @default.
- W2094075461 hasConceptScore W2094075461C2778473898 @default.
- W2094075461 hasConceptScore W2094075461C33009525 @default.
- W2094075461 hasConceptScore W2094075461C33923547 @default.
- W2094075461 hasConceptScore W2094075461C36503486 @default.
- W2094075461 hasConceptScore W2094075461C41008148 @default.
- W2094075461 hasConceptScore W2094075461C54355233 @default.
- W2094075461 hasConceptScore W2094075461C55493867 @default.
- W2094075461 hasConceptScore W2094075461C70721500 @default.
- W2094075461 hasConceptScore W2094075461C78458016 @default.
- W2094075461 hasConceptScore W2094075461C86803240 @default.
- W2094075461 hasLocation W20940754611 @default.
- W2094075461 hasOpenAccess W2094075461 @default.
- W2094075461 hasPrimaryLocation W20940754611 @default.
- W2094075461 hasRelatedWork W1542859148 @default.
- W2094075461 hasRelatedWork W1968674614 @default.
- W2094075461 hasRelatedWork W1971974598 @default.
- W2094075461 hasRelatedWork W1975120703 @default.
- W2094075461 hasRelatedWork W2008545402 @default.
- W2094075461 hasRelatedWork W2013411504 @default.
- W2094075461 hasRelatedWork W2033279214 @default.
- W2094075461 hasRelatedWork W2038819579 @default.
- W2094075461 hasRelatedWork W2048469982 @default.
- W2094075461 hasRelatedWork W2091495631 @default.
- W2094075461 hasRelatedWork W2094852543 @default.
- W2094075461 hasRelatedWork W2096580253 @default.
- W2094075461 hasRelatedWork W2096933265 @default.
- W2094075461 hasRelatedWork W2108926360 @default.
- W2094075461 hasRelatedWork W2122588339 @default.
- W2094075461 hasRelatedWork W2166211110 @default.
- W2094075461 hasRelatedWork W2519544239 @default.
- W2094075461 hasRelatedWork W2897174070 @default.
- W2094075461 hasRelatedWork W2967278580 @default.
- W2094075461 hasRelatedWork W3125178108 @default.
- W2094075461 isParatext "false" @default.
- W2094075461 isRetracted "false" @default.
- W2094075461 magId "2094075461" @default.
- W2094075461 workType "article" @default.