Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094076589> ?p ?o ?g. }
- W2094076589 abstract "Subcutaneous drug implants are convenient systems for the long-term delivery of drugs in animals. Lipid carriers are logical tools because they generally allow for higher doses and low toxicity. The present study used an US Food and Drug Administration Target Animal Safety test system to evaluate the safety of a subcutaneous implant of a cholesterol-triglyceride-buprenorphine powder in 120 BALB/c mice. Mice were evaluated in 4- and 12-day trials with 1- and 5-fold doses of the intended 3 mg/kg dose of drug. One male mouse treated with three 3 mg/kg doses and surgery on days 0, 4, and 8 died on day 9. The cause of death was not determined. In the surviving 119 mice there was no evidence of skin reaction at the site of the implant. Compared to control animals treated with saline, weight measurements, clinical pathology, histopathology, and clinical observations were unremarkable. These results demonstrate that the lipid carrier is substantially safe. Cholesterol-triglyceride-drug powders may provide a valuable research tool for studies of analgesic and inflammatory drug implants in veterinary medicine." @default.
- W2094076589 created "2016-06-24" @default.
- W2094076589 creator A5007301610 @default.
- W2094076589 creator A5010219978 @default.
- W2094076589 creator A5073599277 @default.
- W2094076589 creator A5076104329 @default.
- W2094076589 creator A5087982590 @default.
- W2094076589 date "2014-11-27" @default.
- W2094076589 modified "2023-10-17" @default.
- W2094076589 title "Subcutaneous Implants of Buprenorphine-Cholesterol-Triglyceride Powder in Mice" @default.
- W2094076589 cites W114285100 @default.
- W2094076589 cites W1479971025 @default.
- W2094076589 cites W1619244223 @default.
- W2094076589 cites W1977643393 @default.
- W2094076589 cites W1978744396 @default.
- W2094076589 cites W1990079562 @default.
- W2094076589 cites W1997358606 @default.
- W2094076589 cites W1999683702 @default.
- W2094076589 cites W2024884191 @default.
- W2094076589 cites W2039065745 @default.
- W2094076589 cites W2042368805 @default.
- W2094076589 cites W2049429050 @default.
- W2094076589 cites W2051362749 @default.
- W2094076589 cites W2051416932 @default.
- W2094076589 cites W2053359774 @default.
- W2094076589 cites W2053612042 @default.
- W2094076589 cites W2065754662 @default.
- W2094076589 cites W2067062920 @default.
- W2094076589 cites W2067961086 @default.
- W2094076589 cites W2088668608 @default.
- W2094076589 cites W2093534907 @default.
- W2094076589 cites W2097924984 @default.
- W2094076589 cites W2099947041 @default.
- W2094076589 cites W2102822383 @default.
- W2094076589 cites W2103859861 @default.
- W2094076589 cites W2107997327 @default.
- W2094076589 cites W2143683581 @default.
- W2094076589 cites W2169049131 @default.
- W2094076589 cites W2171087891 @default.
- W2094076589 cites W2401902882 @default.
- W2094076589 cites W2406117937 @default.
- W2094076589 cites W2410130432 @default.
- W2094076589 cites W2411901964 @default.
- W2094076589 cites W27750361 @default.
- W2094076589 cites W2993119859 @default.
- W2094076589 cites W60208364 @default.
- W2094076589 cites W62138238 @default.
- W2094076589 cites W9160839 @default.
- W2094076589 cites W2004860556 @default.
- W2094076589 doi "https://doi.org/10.1155/2014/365673" @default.
- W2094076589 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4590835" @default.
- W2094076589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26464927" @default.
- W2094076589 hasPublicationYear "2014" @default.
- W2094076589 type Work @default.
- W2094076589 sameAs 2094076589 @default.
- W2094076589 citedByCount "6" @default.
- W2094076589 countsByYear W20940765892018 @default.
- W2094076589 countsByYear W20940765892019 @default.
- W2094076589 countsByYear W20940765892020 @default.
- W2094076589 crossrefType "journal-article" @default.
- W2094076589 hasAuthorship W2094076589A5007301610 @default.
- W2094076589 hasAuthorship W2094076589A5010219978 @default.
- W2094076589 hasAuthorship W2094076589A5073599277 @default.
- W2094076589 hasAuthorship W2094076589A5076104329 @default.
- W2094076589 hasAuthorship W2094076589A5087982590 @default.
- W2094076589 hasBestOaLocation W20940765891 @default.
- W2094076589 hasConcept C126322002 @default.
- W2094076589 hasConcept C141071460 @default.
- W2094076589 hasConcept C142724271 @default.
- W2094076589 hasConcept C178790620 @default.
- W2094076589 hasConcept C185592680 @default.
- W2094076589 hasConcept C2777397205 @default.
- W2094076589 hasConcept C2778163477 @default.
- W2094076589 hasConcept C2778913445 @default.
- W2094076589 hasConcept C2779820397 @default.
- W2094076589 hasConcept C2780035454 @default.
- W2094076589 hasConcept C2780820201 @default.
- W2094076589 hasConcept C2781411149 @default.
- W2094076589 hasConcept C29730261 @default.
- W2094076589 hasConcept C42219234 @default.
- W2094076589 hasConcept C544855455 @default.
- W2094076589 hasConcept C71924100 @default.
- W2094076589 hasConcept C98274493 @default.
- W2094076589 hasConceptScore W2094076589C126322002 @default.
- W2094076589 hasConceptScore W2094076589C141071460 @default.
- W2094076589 hasConceptScore W2094076589C142724271 @default.
- W2094076589 hasConceptScore W2094076589C178790620 @default.
- W2094076589 hasConceptScore W2094076589C185592680 @default.
- W2094076589 hasConceptScore W2094076589C2777397205 @default.
- W2094076589 hasConceptScore W2094076589C2778163477 @default.
- W2094076589 hasConceptScore W2094076589C2778913445 @default.
- W2094076589 hasConceptScore W2094076589C2779820397 @default.
- W2094076589 hasConceptScore W2094076589C2780035454 @default.
- W2094076589 hasConceptScore W2094076589C2780820201 @default.
- W2094076589 hasConceptScore W2094076589C2781411149 @default.
- W2094076589 hasConceptScore W2094076589C29730261 @default.
- W2094076589 hasConceptScore W2094076589C42219234 @default.
- W2094076589 hasConceptScore W2094076589C544855455 @default.
- W2094076589 hasConceptScore W2094076589C71924100 @default.
- W2094076589 hasConceptScore W2094076589C98274493 @default.