FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2094094191> ?p ?o ?g. }

• W2094094191 endingPage "735" @default.
• W2094094191 startingPage "726" @default.
• W2094094191 abstract "Over the past years, some members of the family of suppressor of cytokine signalling (SOCS) proteins have emerged as potential tumour suppressors. This study aimed at investigating the clinical significance of SOCS proteins in colorectal carcinoma (CRC).We integrated publicly available microarray expression data on CRC in humans, analysed the expression pattern of SOCSs and assessed the predictive power of SOCS2 and SOCS6 for diagnostic purposes by generating receiver operating characteristic curves. Using laser microdissected patient material we assessed SOCS expression on RNA and protein levels as well as their methylation status in an independent CRC patient cohort. Finally, we investigated the prognostic value of SOCS2 and SOCS6.The meta-analysis as well as the independent patient cohort analysis reveal a stage-independent downregulation of SOCS2 and SOCS6 and identify both molecules as diagnostic biomarkers for CRC. We demonstrate a different methylation pattern within the SOCS2 promoter between tumour tissue and normal control tissue in 25% of CRC patients. Furthermore, early CRC stage patients with low expression of SOCS2 display significantly shorter disease-free survival.Our data offers evidence that SOCS2 and SOCS6 levels are reduced in CRC and may serve as diagnostic biomarkers for CRC patients." @default.
• W2094094191 created "2016-06-24" @default.
• W2094094191 creator A5004325393 @default.
• W2094094191 creator A5013957833 @default.
• W2094094191 creator A5049039471 @default.
• W2094094191 creator A5049939706 @default.
• W2094094191 creator A5054282833 @default.
• W2094094191 creator A5058518069 @default.
• W2094094191 creator A5061510256 @default.
• W2094094191 creator A5067721540 @default.
• W2094094191 creator A5068771650 @default.
• W2094094191 creator A5071215739 @default.
• W2094094191 creator A5075488418 @default.
• W2094094191 creator A5090676241 @default.
• W2094094191 date "2014-07-15" @default.
• W2094094191 modified "2023-10-10" @default.
• W2094094191 title "Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer" @default.
• W2094094191 cites W1506160581 @default.
• W2094094191 cites W1533335653 @default.
• W2094094191 cites W1600880434 @default.
• W2094094191 cites W1712387145 @default.
• W2094094191 cites W1969376484 @default.
• W2094094191 cites W1998107133 @default.
• W2094094191 cites W2002320258 @default.
• W2094094191 cites W2012260662 @default.
• W2094094191 cites W2015725136 @default.
• W2094094191 cites W2025452063 @default.
• W2094094191 cites W2028944165 @default.
• W2094094191 cites W2033079375 @default.
• W2094094191 cites W2036608448 @default.
• W2094094191 cites W2041691476 @default.
• W2094094191 cites W2043693107 @default.
• W2094094191 cites W2049130402 @default.
• W2094094191 cites W2051920991 @default.
• W2094094191 cites W2055973720 @default.
• W2094094191 cites W2061264646 @default.
• W2094094191 cites W2062411397 @default.
• W2094094191 cites W2062736188 @default.
• W2094094191 cites W2072806867 @default.
• W2094094191 cites W2075669383 @default.
• W2094094191 cites W2078120045 @default.
• W2094094191 cites W2089889294 @default.
• W2094094191 cites W2089916965 @default.
• W2094094191 cites W2089991714 @default.
• W2094094191 cites W2090175366 @default.
• W2094094191 cites W2093678620 @default.
• W2094094191 cites W2094139811 @default.
• W2094094191 cites W2098029653 @default.
• W2094094191 cites W2099839360 @default.
• W2094094191 cites W2100859976 @default.
• W2094094191 cites W2105829583 @default.
• W2094094191 cites W2109849382 @default.
• W2094094191 cites W2113676124 @default.
• W2094094191 cites W2114284762 @default.
• W2094094191 cites W2121325450 @default.
• W2094094191 cites W2127594372 @default.
• W2094094191 cites W2135056923 @default.
• W2094094191 cites W2138417195 @default.
• W2094094191 cites W2144177788 @default.
• W2094094191 cites W2146303969 @default.
• W2094094191 cites W2146669435 @default.
• W2094094191 cites W2150007243 @default.
• W2094094191 cites W2150512789 @default.
• W2094094191 cites W2153031009 @default.
• W2094094191 cites W2153206163 @default.
• W2094094191 cites W2153645840 @default.
• W2094094191 cites W2154941270 @default.
• W2094094191 cites W4247623413 @default.
• W2094094191 doi "https://doi.org/10.1038/bjc.2014.377" @default.
• W2094094191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4134506" @default.
• W2094094191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25025962" @default.
• W2094094191 hasPublicationYear "2014" @default.
• W2094094191 type Work @default.
• W2094094191 sameAs 2094094191 @default.
• W2094094191 citedByCount "54" @default.
• W2094094191 countsByYear W20940941912015 @default.
• W2094094191 countsByYear W20940941912016 @default.
• W2094094191 countsByYear W20940941912017 @default.
• W2094094191 countsByYear W20940941912018 @default.
• W2094094191 countsByYear W20940941912019 @default.
• W2094094191 countsByYear W20940941912020 @default.
• W2094094191 countsByYear W20940941912021 @default.
• W2094094191 countsByYear W20940941912022 @default.
• W2094094191 countsByYear W20940941912023 @default.
• W2094094191 crossrefType "journal-article" @default.
• W2094094191 hasAuthorship W2094094191A5004325393 @default.
• W2094094191 hasAuthorship W2094094191A5013957833 @default.
• W2094094191 hasAuthorship W2094094191A5049039471 @default.
• W2094094191 hasAuthorship W2094094191A5049939706 @default.
• W2094094191 hasAuthorship W2094094191A5054282833 @default.
• W2094094191 hasAuthorship W2094094191A5058518069 @default.
• W2094094191 hasAuthorship W2094094191A5061510256 @default.
• W2094094191 hasAuthorship W2094094191A5067721540 @default.
• W2094094191 hasAuthorship W2094094191A5068771650 @default.
• W2094094191 hasAuthorship W2094094191A5071215739 @default.
• W2094094191 hasAuthorship W2094094191A5075488418 @default.
• W2094094191 hasAuthorship W2094094191A5090676241 @default.
• W2094094191 hasBestOaLocation W20940941911 @default.

• next